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SAB4501137

Sigma-Aldrich

Anti-Glucagon antibody produced in rabbit

affinity isolated antibody

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Synonym(s):
Glicentin, Glicentin-related polypeptide, Glucagon-like peptide 1(7-37), Glucagon-like peptide 1(GLP-1), Oxyntomodulin
MDL number:

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 20 kDa

species reactivity

human, rat, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GCG(2641)

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This Item
AB3244G2654SAB4501220
conjugate

unconjugated

conjugate

-

conjugate

unconjugated

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody form

serum

antibody form

ascites fluid

antibody form

affinity isolated antibody

biological source

rabbit

biological source

rabbit

biological source

mouse

biological source

rabbit

technique(s)

ELISA: 1:5000, western blot: 1:500-1:1000, immunofluorescence: 1:100-1:500

technique(s)

ELISA: suitable, radioimmunoassay: suitable

technique(s)

dot blot: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:2,000 using human or animal pancreas, radioimmunoassay: suitable

technique(s)

ELISA: 1:5000, immunofluorescence: 1:100-1:500

form

buffered aqueous solution

form

-

form

-

form

buffered aqueous solution

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General description

Anti-Glucagon antibody detects endogenous levels of total Glucagon protein.
Glucagon-like peptide-1 (GLP-1) is a gastrointestinal hormone. It is a 30-amino acid peptide, that is generated by the intestinal epithelial endocrine L-cells. it is mapped to human chromosome 2q24.

Immunogen

The antiserum was produced against synthesized peptide derived from human Glucagon.

Immunogen Range: 61-110

Application

Anti-glucagon antibody has been used in immunostaining and immunohistochemistry.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Biochem/physiol Actions

Glucagon-like peptide-1 (GLP-1) increases glucose-dependent insulin secretion and terminates the liberation of glucagon. It acts as a physiological regulator of appetite and food intake. GLP-1 also helps to prevent the gastrointestinal movement and secretion.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable


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Expression and regulation of chemokines in murine and human type 1 diabetes
Sarkar SA, et al.
Diabetes, 61(2), 436-446 (2012)
Glucagon-like Peptide-1 Analogues Inhibit Proliferation and Increase Apoptosis of Human Prostate Cancer Cells in vitro
Li XN, et al.
Experimental and Clinical Endocrinology & Diabetes, 125(02), 91-97 (2017)
Reg3? Overexpression Protects Pancreatic Beta-Cells From Cytokine-Induced Damage and Improves Islet Transplant Outcome
Ding Y, et al.
Molecular Medicine, 20(1), 548-548 (2014)
Maria Eriksson et al.
Molecular pharmaceutics, 18(12), 4428-4436 (2021-10-16)
Type 1 diabetes develops in childhood and adolescence, with peak incidence in the early teenage years. There is an urgent need for an accurate method to detect insulin-producing β-cells in patients that is not affected by alterations in β-cell function.
The Physiology of Glucagon-like Peptide 1
Holst JJ
American Physiological Society, 87(4), 1409-1439 (2007)

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