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SAB4700215

Sigma-Aldrich

Monoclonal Anti-CD63 antibody produced in mouse

clone MEM-259, purified immunoglobulin, buffered aqueous solution

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Synonym(s):
Anti-LAMP-3, Anti-ME491, Anti-MLA1, Anti-OMA81H, Anti-TSPAN30
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

MEM-259, monoclonal

form

buffered aqueous solution

species reactivity

human

concentration

1 mg/mL

technique(s)

flow cytometry: suitable

isotype

IgG1

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... CD63(967)

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This Item
SAB4700216SAB4700217SAB4301607
Anti-CD63 affinity isolated antibody

Sigma-Aldrich

SAB4301607

Anti-CD63

conjugate

unconjugated

conjugate

Allophycocyanin conjugate

conjugate

FITC conjugate

conjugate

-

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

clone

MEM-259, monoclonal

clone

MEM-259, monoclonal

clone

MEM-259, monoclonal

clone

polyclonal

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous glycerol solution

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human, mouse

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General description

Cluster of differentiation 63 (CD63), also known as melanoma 1 antigen, is encoded by the gene mapped to human chromosome 12q13.2. The encoded protein belongs to the transmembrane 4 superfamily (TM4SF). CD63 is an integral membrane glycoprotein expressed in late endosomes and lysosomes and is also present in the platelet dense granule membrane.
The antibody MEM-259 reacts with CD63 (LAMP-3), a 40-60 kDa tetraspan glycoprotein expressed by granulocytes, platelets, T cells, monocytes/macrophages and endothelial cells. Cell surface exposition of CD63 is usually activation-dependent.

Immunogen

HPB-ALL T cell line

Application

Monoclonal Anti-CD63 antibody produced in mouse has been used in flow cytometry and confocal imaging.
The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 2 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Biochem/physiol Actions

Cluster of differentiation 63 (CD63) is one of the platelet activation marker, which plays a vital role in platelet aggregation, adhesion to collagen, uptake of oxidized low-density lipoprotein (LDL) in vitro and regulation of angiogenesis. Inadequate expression of CD63 results in the autosomal recessive inherited disorder, Hermansky-Pudlak syndrome. CD63 is associated with various cellular functions, such as cellular adhesion, cell differentiation, migration, carcinogenesis and tumor progression. CD63 is highly expressed in the initial stage of Merkel cell carcinoma and decreased in later stages; therefore, CD63 is considered to be a potential prognostic factor for this malignancy.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Gene expression signature associated with BRAF mutations in human primary cutaneous melanomas
Kannengiesser C
Molecular Oncology, 1, 425-430 (2008)
Jayanthi Lea et al.
Oncotarget, 8(9), 14395-14407 (2017-01-26)
There are no suitable screening modalities for ovarian carcinomas (OC) and repeated imaging and CA-125 levels are often needed to triage equivocal ovarian masses. Definitive diagnosis of malignancy, however, can only be established by histologic confirmation. Thus, the ability to
Tra-Ly Nguyen et al.
Cancer research, 78(18), 5384-5397 (2018-07-29)
The mTOR is a central regulator of cell growth and is highly activated in cancer cells to allow rapid tumor growth. The use of mTOR inhibitors as anticancer therapy has been approved for some types of tumors, albeit with modest
Expression of the tetraspanins CD9, CD37, CD63, and CD151 in Merkel cell carcinoma: strong evidence for a posttranscriptional fine-tuning of CD9 gene expression.
Woegerbauer M
Modern Pathology, 23, 751-762 (2010)
The protein CD63 is in platelet dense granules, is deficient in a patient with Hermansky-Pudlak syndrome, and appears identical to granulophysin.
Nishibori M
The Journal of Clinical Investigation, 91, 1775-1782 (1993)

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