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SML0886

Sigma-Aldrich

Leukadherin-1

≥98% (HPLC)

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Synonym(s):
4-[5-[[4-Oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-benzoic acid, LA1, Leukadhedrin 1, Leukadherin 1
Empirical Formula (Hill Notation):
C22H15NO4S2
CAS Number:
Molecular Weight:
421.49
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

powder

color

, yellow to orange to brown

solubility

DMSO: 3 mg/mL, clear (warmed)

storage temp.

2-8°C

InChI

1S/C22H15NO4S2/c24-20-19(29-22(28)23(20)13-14-4-2-1-3-5-14)12-17-10-11-18(27-17)15-6-8-16(9-7-15)21(25)26/h1-12H,13H2,(H,25,26)/b19-12-

InChI key

AEZGRQSLKVNPCI-UNOMPAQXSA-N

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This Item
434610SML0943M5449
Sigma-Aldrich

SML0886

Leukadherin-1

Leukadherin-1 A furanyl thiazolidinone compound that binds CD11b αA/αI domain in a reversible manner and stabilizes αA in a high-affinity binding conformation toward known CD11b/CD18 (αMβ2; CR3; Mac-1) ligands, fibrinogen, ICAM-1, and iC3B.

434610

Leukadherin-1

Sigma-Aldrich

SML0943

YM-1

MKT-077 ≥98% (HPLC), powder

M5449

MKT-077

form

powder

form

solid

form

powder

form

powder

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 3 mg/mL, clear (warmed)

solubility

DMSO: 5 mg/mL, yellow

solubility

H2O: 2 mg/mL, clear (warmed)

solubility

H2O: 10 mg/mL, clear

color

, yellow to orange to brown

color

red-brown

color

orange to dark red

color

orange to red

Biochem/physiol Actions

Leukadherin-1 is an agonist of complement receptor-3 (CR3) and exhibits anti-inflammatory activity. It is an allosteric agonist that activates integrin by binding to a different site from the ligand binding. Leukadherin-1 plays an important role in the margination and adhesion of neutrophils to the endothelial lining of the blood vessels.
Leukadherin-1 is an agonist of integrin CD11b/CD18 that can increase the extent of CD11b/CD18-dependent cell adhesion of transfected cells and of primary human and mouse neutrophils. Also, Leukadherin-1 decreases leukocyte recruitment and reduced arterial narrowing after injury in rats.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Catherine M Dickinson et al.
Journal of intensive care, 6, 19-19 (2018-03-24)
Multi-organ failure occurs during critical illness and is mediated in part by destructive neutrophil-to-endothelial interactions. The β2 integrin receptor, CR3 (complement receptor 3; Mac-1; CD11b/CD18), which binds endothelial intercellular adhesion molecule-1 (ICAM-1), plays a key role in promoting the adhesion

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