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T3309

Sigma-Aldrich

Transferrin human

≥98%

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Synonym(s):
Siderophilin, partially saturated
CAS Number:
EC Number:
MDL number:
NACRES:
NA.61

biological source

human

Quality Level

assay

≥98%

form

powder

Iron content

300-600 ppm

technique(s)

cell culture | stem cell: suitable

impurities

≤1.0 EU/mg endotoxin

UniProt accession no.

storage temp.

2-8°C

Gene Information

human ... TF(7018)

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This Item
SRP6472T8158T4132
vibrant-m

T3309

Transferrin human

vibrant-m

SRP6472

Transferrin human

vibrant-m

T8158

Transferrin human

vibrant-m

T4132

holo-Transferrin human

biological source

human

biological source

human

biological source

-

biological source

human

technique(s)

cell culture | stem cell: suitable

technique(s)

-

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

impurities

≤1.0 EU/mg endotoxin

impurities

<1 EU/μg endotoxin (LAL test)

impurities

endotoxin, tested, hepatitis and HIV antibody, none detected

impurities

HIV, hepatitis B and hepatitis C, none detected

Gene Information

human ... TF(7018)

Gene Information

human ... TF(7018)

Gene Information

human ... TF(7018)

Gene Information

human ... TF(7018)

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

General description

Transferrin is an 80 kDa serum glycoprotein, which has an half-life of 8 to 10 days. The gene is located on human chromosome 3q22.1. Transferrin is expressed in hepatocytes.

Application

Transferrin has been used:
  • in isolation of epidermal stem cells and cell expansion
  • to study the effect of compound treatment on transferrin uptake
  • for transferrin uptake and confocal imaging

Biochem/physiol Actions

Transferrin facilitates the transfer of iron to erythron and peripheral tissues. Mutations in this gene is associated with atransferrinemia. Transferrin is required for fetal development. It is non immunogenic and transferrin-conjugated drugs inhibits cardiotoxicity and drug resistance.
Transferrin was shown to promote the proliferation of human lymphocytes. This effect is directly proportional to the level of iron present.

Analysis Note

Purity by agarose electrophoresis.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3


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The effect of different forms of iron and iron-binding proteins on the proliferative response of human lymphocytes to phytohaemagglutinin (PHA) has been studied. Transferrin enhanced proliferation, the effect being proportional to the degree of iron saturation up to 100%, but

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