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T2252

Sigma-Aldrich

apo-Transferrin human

≥95% protein basis (biuret)

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Synonym(s):
Human transferrin, Siderophilin
CAS Number:
EC Number:
MDL number:
NACRES:
NA.61

biological source

human

Quality Level

Assay

≥95% protein basis (biuret)
≥98% (agarose gel electrophoresis)

form

powder

mol wt

76-81 kDa

technique(s)

cell culture | mammalian: suitable

solubility

H2O: 50 mg/mL

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... TF(7018)

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This Item
T4382T5391T4132
apo-Transferrin human ≥95% protein basis (biuret)

Sigma-Aldrich

T2252

apo-Transferrin human

apo-Transferrin human powder, ≥98% (agarose gel electrophoresis)

Sigma-Aldrich

T4382

apo-Transferrin human

Sigma-Aldrich

Sigma-Aldrich

T5391

apo-Transferrin human

holo-Transferrin human ≥98%

Sigma-Aldrich

T4132

holo-Transferrin human

assay

≥95% protein basis (biuret), ≥98% (agarose gel electrophoresis)

assay

≥98% (agarose gel electrophoresis)

assay

≥98%

assay

≥98%

form

powder

form

powder

form

powder

form

powder

mol wt

76-81 kDa

mol wt

76-81 kDa

mol wt

76-81 kDa

mol wt

-

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

solubility

H2O: 50 mg/mL

solubility

H2O: 50 mg/mL

solubility

H2O: 50 mg/mL

solubility

-

General description

Transferrin is a bilobed glycoprotein containing an N-terminal lobe and a C-terminal lobe. Each of these domains is divided into two sub-domains and within the inter subdomain cleft is the metal-binding site. A single transferrin molecule can bind to two ferric ions. Apo-transferrin is an iron-free form.

Application

Apo-transferrin has been shown to strongly inhibit bacterial adhesion to biomaterials including polystyrene, polymethylmethacrylate, and silicone. Inhibition was seen at twenty micrograms/ml in culture medium.
apo-Transferrin human has been used in Dulbecco′s Modified Eagle Medium/Nutrient Mixture F-12 to culture:
  • pancreatic ductal adenocarcinoma (PDAC) cell lines
  • oligodendrocytes
  • renal proximal tubule epithelial cells (RPTEC/TERT1) cells

Biochem/physiol Actions

Transferrin transports iron through receptor-mediated endocytosis. The iron transport mechanism occurs in the endothelial cells of the blood-brain barrier. Transferrin maintains iron homeostasis and is an iron-associated marker. Reduced levels of transferrin are observed in severe COVID-19 conditions. It may bind to other molecules apart from iron, hence it can be used in targeted drug delivery.

Other Notes

Non-heme iron-transport protein.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3


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Customers Also Viewed

Camila Campos-Escamilla et al.
International journal of molecular sciences, 22(24) (2021-12-25)
Human serum transferrin (Tf) is a bilobed glycoprotein whose function is to transport iron through receptor-mediated endocytosis. The mechanism for iron release is pH-dependent and involves conformational changes in the protein, thus making it an attractive system for possible biomedical
Reza Ardehali et al.
Artificial organs, 26(6), 512-520 (2002-06-20)
Apo-transferrin (apo-Tf), the iron deficient form of Tf, has been identified previously as a potent inhibitor of Staphylococcus epidermidis adhesion to polyurethane surfaces. In this study, the ability of apo-Tf to suppress the adhesion of two other strains of bacteria
Catherine Claise et al.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 116, 74-79 (2021-12-25)
Mounting evidence links hyperinflammation in gravely ill patients to low serum iron levels and hyperferritinemia. However, little attention has been paid to other iron-associated markers such as transferrin. The aim of this study was to investigate the association of different
Jacob M Smigiel et al.
Molecular cancer research : MCR, 15(4), 478-488 (2017-01-06)
Pancreatic ductal adenocarcinoma (PDAC) is referred to as a silent killer due to the lack of clear symptoms, a lack of early detection methods, and a high frequency of metastasis at diagnosis. In addition, pancreatic cancer is remarkably resistant to
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In breast cancer, various clinical parameters are assessed to define clinical stage and thus obtain a more accurate prognosis. However, banks of tumor tissues are an important source of material for studies of risk of recurrence and of features governing

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