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T4382

Sigma-Aldrich

apo-Transferrin human

powder, ≥98% (agarose gel electrophoresis)

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Synonym(s):
Human transferrin, Siderophilin
CAS Number:
EC Number:
MDL number:

biological source

human

Quality Level

assay

≥98% (agarose gel electrophoresis)

form

powder

mol wt

76-81 kDa

Iron content

≤0.005%

technique(s)

cell culture | mammalian: suitable

impurities

HIV and HBsAg, source material tested negative

solubility

H2O: 50 mg/mL

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... TF(7018)

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General description

Apo-transferrin human is a glycoprotein, possessing homologous carboxyl and amino domain. Both the domain binds to one molecule of iron. Only 30% of transferrin is saturated with iron in the amino domain. Apo-transferrin in human is encoded by the gene TF which is localized on human chromosome 3q22.1.

Application

Apo-Transferrin human has been used:
  • to determine the competitive binding of bismuth to albumin and transferrin by fast performance liquid chromatography (FPLC)
  • to study titanium-transferrin complex by electrochemical method
  • in the preparation of transferrin solution and in the formation of conjugates with ruthenium-complexes for cellular viability studies

Biochem/physiol Actions

Apo-transferrin is an iron transport protein. The concentration of transferrin in blood plasma is about 35 μM. Transferrin also functions in the transport of therapeutic, diagnostic and toxic ions like Ga3+, Ru3+ and Al3+. Polymorphism in TF gene has pathological implications in Parkinson′s disease.
Apo-transferrin is required for the survival and differentiation of oligodendroglial cells.

Other Notes

Non-heme iron-transport protein.

Linkage

Similar to T 2252

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3


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Articles

Understand how transferrin affects serum-free cell culture systems, crucial for biomanufacturing heterologous proteins like monoclonal antibodies.

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