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T1428

Sigma-Aldrich

apo-Transferrin bovine

BioReagent, suitable for cell culture, ≥98%

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Synonym(s):
Human serotransferrin
CAS Number:
11096-37-0
EC Number:
234-318-8
MDL number:
MFCD00130536
NACRES:
NA.83

biological source

bovine

Quality Level

200

product line

BioReagent

Assay

≥98%

form

powder

technique(s)

cell culture | mammalian: suitable

impurities

iron, essentially free

solubility

H2O: 10 mg/mL

UniProt accession no.

Q29443

storage temp.

2-8°C

Gene Information

bovine ... TF(280705)

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This Item
T0178T4132T2036
apo-Transferrin bovine BioReagent, suitable for cell culture, ≥98%

Sigma-Aldrich

T1428

apo-Transferrin bovine

apo-Transferrin bovine ≥98%

Sigma-Aldrich

T0178

apo-Transferrin bovine

holo-Transferrin human ≥98%

Sigma-Aldrich

T4132

holo-Transferrin human

apo-Transferrin human powder, BioReagent, suitable for cell culture, ≥98% (agarose gel electrophoresis)

Sigma-Aldrich

T2036

apo-Transferrin human

assay

≥98%

assay

≥98%

assay

≥98%

assay

≥98% (agarose gel electrophoresis)

form

powder

form

powder

form

powder

form

powder

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

impurities

iron, essentially free

impurities

-

impurities

HIV, hepatitis B and hepatitis C, none detected

impurities

HIV and HBsAg, source material tested negative, endotoxin, tested

solubility

H2O: 10 mg/mL

solubility

H2O: 20 mg/mL

solubility

-

solubility

H2O: 50 mg/mL

General description

apo-Transferrin is an iron-free form of transferrin that is present in circulation.

Application

All cells require iron for the proper uptake of oxygen from their environment. Transferrin, a protein isolated from serum, causes the uptake and transport of iron from culture medium to the cells. This allows proper oxygen uptake and also stimulates growth-related enzyme activity. Iron-saturated transferrin (holo transferrin) is continually recycled after releasing iron and becomes iron-deficient transferrin (apo-transferrin). Choosing which form to use depends upon the culture conditions. In media such as Dulbecco′s Modified Eagle′s Medium/Ham′s Nutrient Mixture F12 (DMEM/F12) that contain high levels of iron salt, using apo-transferrin is preferred.
apo-Transferrin bovine has been used as a component of:
  • basal medium for culturing bovine mammary epithelial cells
  • minimum essential medium α (MEM-α) for spermatogonial stem cells (SSCs) culture
  • induction medium for mesenchymal stem cell culture

Biochem/physiol Actions

apo-Transferrin (apoTf) aids in preventing iron accumulation in tissues, especially in non-transfusion dependent β-thalassemia.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Transferrin, Holo, Bovine Plasma

Shanshan Li et al.
Journal of animal science and biotechnology, 7, 44-44 (2016-08-06)
The objective of this study was to study how changing the ratio of Lys to Thr, Lys to His, and Lys to Val affects the expression of lipogenic genes and microRNA (miRNA) in bovine mammary epithelial cells. Triplicate cultures with
Jia Wang et al.
Stem cell research & therapy, 10(1), 227-227 (2019-07-31)
High temperature has a very adverse effect on mammalian spermatogenesis and eventually leads to sub- or infertility through either apoptosis or DNA damage. However, the direct effects of heat stress on the development of spermatogonial stem cells (SSCs) are still
Function and therapeutic development of apotransferrin.
Jaakko Parkkinen et al.
Vox sanguinis, 83 Suppl 1, 321-326 (2003-03-06)
Keita Abe et al.
Zeitschrift fur Naturforschung. C, Journal of biosciences, 63(1-2), 154-156 (2008-04-05)
We have investigated the mechanism of manganese ion uptake by apo-transferrin using a capillary electrophoresis method, and obtained clear evidence that oxidation state +3 and the binuclear unit of a manganese chelate are essential factors for the facile uptake by
Einar Vargas-Bello-Pérez et al.
Animal nutrition (Zhongguo xu mu shou yi xue hui), 5(2), 202-208 (2019-06-14)
The objective of this study was to determine how cytosolic triacylglycerols (TAG) are stored in mammary cells and whether this depends on the individual chemical configuration of fatty acids (FA). This objective was accomplished by addition of different FA to
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