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P5155

Sigma-Aldrich

D-Pantothenic acid hemicalcium salt

BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture

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Synonym(s):
(R)-(+)-N-(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)-β-alanine hemicalcium salt, Calcium D-pantothenate, Vitamin B5
Linear Formula:
HOCH2C(CH3)2CH(OH)CONHCH2CH2CO2 ·1/2Ca
CAS Number:
Molecular Weight:
238.27
Beilstein:
3769272
EC Number:
MDL number:
eCl@ss:
34058012
PubChem Substance ID:
NACRES:
NA.75

biological source

synthetic (organic)

Quality Level

product line

BioReagent

Assay

≥98% (TLC)

form

powder

mol wt

Mw 238.27 g/mol

technique(s)

cell culture | insect: suitable
cell culture | mammalian: suitable
cell culture | plant: suitable

color

white to off-white

pH

7.0-8 (25 °C, 50 g/L)

solubility

water: soluble 50 mg/mL, clear, colorless

storage temp.

2-8°C

SMILES string

CC(C)(CO)[C@@H](O)C(=O)NCCC(=O)O[Ca]OC(=O)CCNC(=O)[C@H](O)C(C)(C)CO

InChI

1S/2C9H17NO5.Ca/c2*1-9(2,5-11)7(14)8(15)10-4-3-6(12)13;/h2*7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13);/q;;+2/p-2/t2*7-;/m00./s1

InChI key

FAPWYRCQGJNNSJ-UBKPKTQASA-L

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This Item
21210PHR1232C8731
Calcium-d-pantothenate Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1232

Calcium-d-pantothenate

Calcium pantothenate meets USP testing specifications, monograph mol wt. 476.53 (C18H32CaN2O10)

Sigma-Aldrich

C8731

Calcium pantothenate

form

powder

form

powder or crystals

form

-

form

crystalline, powder

mol wt

Mw 238.27 g/mol

mol wt

-

mol wt

-

mol wt

monograph mol wt. 476.53 (C18H32CaN2O10)

technique(s)

cell culture | insect: suitable, cell culture | mammalian: suitable, cell culture | plant: suitable

technique(s)

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

cell culture | mammalian: suitable, cell culture | plant: suitable

color

white to off-white

color

white

color

-

color

white

solubility

water: soluble 50 mg/mL, clear, colorless

solubility

H2O: 50 mg/mL at 25 °C, clear, almost colorless

solubility

-

solubility

-

General description

Plants and microorganisms, such as Escherichia coli are the major sources of D-pantothenic acid. It is water soluble and quite stable to heating.

Application

D-Pantothenic acid hemicalcium salt has been used:
  • as a component of FMX-turbodoma- derived media
  • as a supplement in DMEM (Dulbecco′s modified eagle media)/F-12 used for cell proliferation
  • as a supplement in preadipocyte media

Precursor in the biosynthesis of coenzyme A.

Biochem/physiol Actions

Along with coenzyme A (CoA, D-pantothenic acid is a precursor for acyl carrier protein. These are essential cofactors involved in fat, protein and carbohydrate metabolism. It also participates in the formation of acetylcholine neurotransmitter. D-pantothenic acid is considered as a source of nutrition and possesses immune function by mediating antibody formation. The production of cortisone is supported by D-pantothenic acid. It is essential for adrenal gland activity.

Physical properties

Due to the unstable, hygroscopic nature of the free acid, the calcium salt is employed.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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25G
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3T3-L1 cells and perivascular adipocytes are not equivalent in amine transporter expression
Ismail A, et al.
Febs Letters, 591(1), 137-144 (2017)
Stopping the Clock, 184-184 (2003)
LipiD-QuanT: a novel method to quantify lipid accumulation in live cells.
Varinli H, et al.
Journal of Lipid Research, 56(11), 2206-2216 (2015)
Organisation of the pantothenate (vitamin B5) biosynthesis pathway in higher plants
Ottenhof HH, et al.
The Plant Journal, 37(1), 61-72 (2004)
The role of vitamins and amino acids on hybridoma growth and monoclonal antibody production
Ducommun P, et al.
Cytotechnology, 37(2), 65-73 (2001)

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