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SML3446

Sigma-Aldrich

VT107

≥98% (HPLC)

Synonym(s):

(S)-N-(l-(6-Aminopyridin-2-yl)ethyl)-5-(4-(trifluoromethyl)phenyl)-2-naphthamide, N-[(1S)-1-(6-Amino-2-pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxamide, VT 107

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About This Item

Empirical Formula (Hill Notation):
C25H20F3N3O
CAS Number:
Molecular Weight:
435.44
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

Pricing and availability is not currently available.

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

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VT107 ≥98% (HPLC)

SML3446

VT107

VT104 ≥98% (HPLC)

SML3445

VT104

VCP746 ≥98% (HPLC)

SML3561

VCP746

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

white to beige

Biochem/physiol Actions

VT107 is a potent pan-TEAD auto-palmitoylation inhibitor (3 μM; using TEAD isotype-overexpressing HEK293T) that blocks TEAD-mediated gene transcription (IC50 = 4.93 nM) by preventing its association with YAP/TAZ. VT107 selectively inhibits the proliferation of mesothelioma cultures with NF2 mutation (NCI-H2051 IC50 = 20.4 nM), deletion (NCI-H2373 IC50 = 9.35 nM) or deficiency (NCI-H226 IC50 = 8.67 nM), but not those with wild-type NF2.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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    Manon Sturbaut et al.
    European journal of medicinal chemistry, 226, 113835-113835 (2021-09-13)
    The Hippo pathway is involved in organ size control and tissue homeostasis by regulating cell growth, proliferation and apoptosis. It controls the phosphorylation of the transcription co-activator YAP (Yes associated protein) and TAZ (Transcriptional coactivator with PDZ-binding motif) in order
    Tracy T Tang et al.
    Molecular cancer therapeutics, 20(6), 986-998 (2021-04-15)
    Mutations in the neurofibromatosis type 2 (NF2) gene that limit or abrogate expression of functional Merlin are common in malignant mesothelioma. Merlin activates the Hippo pathway to suppress nuclear translocation of YAP and TAZ, the major effectors of the pathway

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