SRP0300
TGF-β1 Latent human
recombinant, expressed in FreeStyle™ 293-F cells, ≥98% (SDS-PAGE)
Synonym(s):
LAP, TGFb1, TGFbeta1, latency-associated peptide, transforming growth factor beta-1
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
Pricing and availability is not currently available.
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General description
Human TGFβ1 (GenBank Accession No. NM_000660), amino acids 30-390 (end) with Cys33Ser mutation and N-terminal His-tag, disulfide-linked homodimers of TGFβ1 LAP and mature TGFβ1, MW= ~75kDa and 25kDa, under non-reducing conditions.
LTBP1 (latent transforming growth factor β binding protein 1) belongs to the LTBP family of proteins.[1] The protein has 18 epidermal growth factor (EGF)-like repeats and four LTBP-like repeats.[2] The gene is mapped to human chromosome 2p22.3.[3]
LTBP1 (latent transforming growth factor β binding protein 1) belongs to the LTBP family of proteins.[1] The protein has 18 epidermal growth factor (EGF)-like repeats and four LTBP-like repeats.[2] The gene is mapped to human chromosome 2p22.3.[3]
Application
Useful for cell culture and for the study of signaling and apoptotic pathways.
Biochem/physiol Actions
LTBP1 (latent transforming growth factor β binding protein 1) is an extracellular matrix protein which also controls TGF-β (transforming growth factor β) bioavailability. LTBP1 is mainly responsible for the folding and secretion of TGF-β, thereby adding it to the extracellular matrix. It is a target of HTRA1 (high temperature requirement protein A1), a serine protease involved in cellular signaling.[1][4]
Physical form
Lyophilized from a 0.2 μM filtered, aqueous solution.
Reconstitution
Reconstitute in sterile PBS with 0.1% BSA. Stability: >6 months at –70°C (as a solid). Store reconstituted protein in aliquots at –80°C for up to 3 months. Avoid freeze/thaw cycles.
Legal Information
FreeStyle is a trademark of Invitrogen Corp.
Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Cerebral small vessel disease-related protease HtrA1 processes latent TGF-? binding protein 1 and facilitates TGF-? signaling.
Beaufort N, et al.
Proceedings of the National Academy of Sciences of the USA, 111, 16496-16501 (2014)
NMR spectroscopic and bioinformatic analyses of the LTBP1 C-terminus reveal a highly dynamic domain organisation.
Robertson IB, et al.
PLoS ONE, 9, e87125-e87125 (2014)
A suite of novel human spermatozoal RNAs.
Ostermeier GC, et al.
Journal of Andrology, 26, 70-74 (2005)
Association of the small latent transforming growth factor-beta with an eight cysteine repeat of its binding protein LTBP-1.
Saharinen J, et al.
The Embo Journal, 15, 245-253 (1996)
L Bourdrel et al.
Protein expression and purification, 4(2), 130-140 (1993-04-01)
A partial cDNA clone encoding the gene for human transforming growth factor-beta 1 (TGF-beta 1) was isolated from a human bladder carcinoma cell line (5637) cDNA library. Following restriction enzyme processing and ligation of synthetic oligonucleotide linkers, the gene was
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