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T2943

Sigma-Aldrich

Tissue plasminogen activator chromogenic substrate

≥95% (HPLC), solid

Synonym(s):

TPA Activity Assay

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About This Item

MDL number:
UNSPSC Code:
12352204
NACRES:
NA.32

Quality Level

assay

≥95% (HPLC)

form

solid

mol wt

apparent mol wt 658.9

solubility

methanol: water (1:9): 25 mg/mL

Storage temp.

2-8°C

General description

Tissue plasminogen activator chromogenic substrate is a highly sensitive chromogenic peptide substrate for tissue plasminogen activator (tPA). It shows different sensitivity to native single-chain tPA (sc-tPA) and its fully active two-chain form (tc-tPA).

Application

Tissue plasminogen activator chromogenic substrate has been used:
  • in tissue plasminogen activator inhibition assay
  • to determine the plasminogen activator (PA) activity by studying the glycosylation properties of tissue plasminogen activator (tPA) activities in effusions using concanavalin A-Sepharose (conA-S) chromatography
  • in inhibition assays and complex formation analyses of wild type (WT) neuroserpin (NS) and its variants

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Certificates of Analysis (COA)

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Mahdieh Bayat et al.
Journal of biotechnology, 280, 1-10 (2018-05-29)
The aim of the present study was to investigate the effect of three routine drug excipients, as osmolytes, in three different concentrations, on structure, thermal stability and the activity of single-chain (sc-) tenecteplase. To see the influence of trehalose, mannitol
Jesse Cahill et al.
Frontiers in molecular biosciences, 7, 574477-574477 (2020-10-08)
Although chemically inert, Xe and other noble gases have been shown to have functional effects on biological systems. For example, Xe is a powerful anesthetic with neuroprotective properties. Recent reports have claimed that Xe inhibits the activity of tissue plasminogen
Mahdieh Bayat et al.
International journal of biological macromolecules, 130, 863-877 (2019-03-09)
Organic osmolytes, as major cellular compounds, cause protein stabilization in the native form. In the present study, the possible chaperone effects of the three naturally occurring osmolytes on the two-chain form of tenecteplase (tc-TNK), a recombinant, genetically engineered mutant tissue
Mohammad Farhan Ali et al.
Scientific reports, 7, 42987-42987 (2017-02-24)
Neuroserpin (NS) mediated inhibition of tissue-type plasminogen activator (tPA) is important for brain development, synapse formation and memory. Aberrations in helix F and β-sheet A movement during inhibition can directly lead to epilepsy or dementia. Conserved W154 residue in a
Mark W C Hatton et al.
The Journal of laboratory and clinical medicine, 147(1), 27-35 (2006-01-31)
The VX2 tumor is derived from a papilloma virus-induced rabbit epithelial cell line. If VX2 tumor cells (trapped in a plasma clot) are introduced intravenously into NZW rabbits, the cells lodge in the lung capillary bed and produce tumors. Independently

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