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T8637

Sigma-Aldrich

Thiamine monophosphate chloride dihydrate

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Synonym(s):
Aneurine monophosphate chloride
Empirical Formula (Hill Notation):
C12H18ClN4O4PS · 2H2O
CAS Number:
Molecular Weight:
416.82
Beilstein/REAXYS Number:
3844977
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.79

biological source

synthetic

Quality Level

assay

≥99.0% (HPLC)

form

powder

technique(s)

HPLC: suitable

color

white to off-white

mp

190 °C

storage temp.

2-8°C

SMILES string

[Cl-].Cc1ncc(C[n+]2csc(CCOP(O)(O)=O)c2C)c(N)n1

InChI

1S/C12H17N4O4PS.ClH/c1-8-11(3-4-20-21(17,18)19)22-7-16(8)6-10-5-14-9(2)15-12(10)13;/h5,7H,3-4,6H2,1-2H3,(H3-,13,14,15,17,18,19);1H

InChI key

GUGWNSHJDUEHNJ-UHFFFAOYSA-N

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1 of 4

This Item
T4625T4562T1270
Thiamine hydrochloride reagent grade, ≥99% (HPLC)

T4625

Thiamine hydrochloride

Essential Grade
Thiamine hydrochloride meets USP testing specifications

T4562

Thiamine hydrochloride

-
Thiamine hydrochloride BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture

T1270

Thiamine hydrochloride

-
biological source

synthetic

biological source

synthetic (organic)

biological source

synthetic (organic)

biological source

synthetic (organic)

assay

≥99.0% (HPLC)

assay

≥99% (HPLC)

assay

98.0-102.0%

assay

≥99.0% (HPLC)

form

powder

form

powder

form

solid

form

powder

storage temp.

2-8°C

storage temp.

-

storage temp.

-

storage temp.

-

color

white to off-white

color

white

color

-

color

white

Application

Thiamine monophosphate chloride dihydrate has been used as a standard in high-performance liquid chromatography (HPLC) to quantify thiamine in plant exudates and to evaluate its purity.

Biochem/physiol Actions

Thiamine monophosphate (TMP) is used as a substrate of thiamine-phosphate kinase (EC 2.7.4.16) and a precursor of thiamine pyrophosphate (TPP). TPP is a coenzyme involved in the catabolism of sugars and amino acids.
Thiamine monophosphate (TMP) is used as a substrate of thiamine-phosphate kinase (EC 2.7.4.16) and a precursor of thiamine pyrophosphate (TPP). TPP is a coenzyme involved in the catabolism of sugars and amino acids. TMP acts as an intermediate in the hydrolysis of thiamine pyrophosphate to thiamine.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Thiamine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material

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Thiamine hydrochloride BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture

Sigma-Aldrich

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D-(+)-Turanose ≥98%

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Aminoff's Neurology and General Medicine, 47(12) (2014)
Purity of standard solutions of thiamine and its phosphate esters for HPLC analysis
Ihara H, et al.
Journal of Analytical Bio-Science, 25(3) (2002)
M Héroux et al.
Neurochemical research, 20(1), 87-93 (1995-01-01)
Thiamine phosphate esters (thiamine monophosphate-TMP; thiamine diphosphate-TDP and thiamine triphosphate-TTP) were measured as their thiochrome derivatives by High Performance Liquid Chromatography in the brains of pyrithiamine-treated rats at various stages during the development of thiamine deficiency encephalopathy. Severe encephalopathy was
M Héroux et al.
Metabolic brain disease, 11(1), 81-88 (1996-03-01)
There is a growing body of evidence to suggest that thiamine neurochemistry is disrupted in Alzheimer's Disease (AD). Studies in autopsied brain tissue from neuropathologically proven AD patients reveal significantly reduced activities of the thiamine phosphate dephosphorylating enzymes thiamine diphosphatase
New Research and Developments of Water-Soluble Vitamins (2018)

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