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TRUECD

Sigma-Aldrich

TrueGel3D Crosslinker

CD cell-degradable crosslinker

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shipped in

dry ice

storage temp.

−20°C

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TRUECD

TrueGel3D Crosslinker

vibrant-m

TRUE8

TrueGel3D Hydrogel Kits

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TRUE7

TrueGel3D Hydrogel Kits

vibrant-m

TRUE6

TrueGel3D Hydrogel Kits

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

General description

CD cell-degradable crosslinker is comprised of conjugated peptide along with polyethylene glycol and thiol (SH) groups. The thiol groups form stable thioether bond with thiol-reactive groups of the polymers (Mal-PVA, Mal-Dextran, SG-PVA and SG-Dextran) and results in a stable hydrogel.

The conjugated peptide has matrix metalloprotease (MMP)-cleavage sites (Pro-Leu-Gly-Leu-Trp-Ala), which allows matrix metalloproteases (MMP1, MMP3, MMP7 and MMP9) to locally degrade the polymer network. It allows cells to spread and migrate within the gel if they express the indicated MMPs.

Application

TRUECD is used to crosslink PVA and dextran polymers to generate cell-degradable hydrogel

Features and Benefits

MMP degradable

Components

TRUECD contains CD cell-degradable crosslinker lyophilized and water.

Caution

Avoid prolong exposure of CD cell-degradable crosslinker to air

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3


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Customers Also Viewed

Articles

The TrueGel3D™ hydrogel is formed by crosslinking RGD (arginylglycylaspartic acid) degradable polymer with CD cell-degradable crosslinker. Troubleshoot hydrogel formation and cell viability with this article.

TrueGel3D™ is a synthetic hydrogels platform for 3D cell culture that aim to mimic the natural extracellular environment for more physiological culture conditions

Protocols

TrueGel3D™ is chemically defined hydrogel, enables cell growth in 3D environment and mimics native tissue environment. Slow gelation facilitates filling of microchannels or syringes. Find detail protocol of slow gelation for TrueGel3D™ kits

TrueGel3D™ is a chemically-defined hydrogel formed by mixing polymers with crosslinkers. This hydrogel permits the encapsulation of cells to put them in a three-dimensional environment to better mimic the native tissue environment.

An advanced protocol is available for TrueGel 3D kits for 3D cell culture for peptides concentration or stiffness optimisation

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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