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Anti-GAP43 Antibody, clone 1D6 , ZooMAb® Rabbit Monoclonal

enhanced validationgreener alternative

recombinant, expressed in HEK 293 cells

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Axonal membrane protein GAP-43, Growth-associated protein 43, Neural phosphoprotein B-50, Neuromodulin, pp46

biological source

rabbit (recombinant)

Quality Level


expressed in HEK 293 cells



antibody form

purified antibody

antibody product type

primary antibodies


1D6, recombinant monoclonal

product line

ZooMAb® learn more



mol wt

calculated mol wt 24.8 kDa
observed mol wt ~47 kDa

species reactivity



antibody small pack of 25 μL

greener alternative product characteristics

Waste Prevention
Designing Safer Chemicals
Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation


immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable



UniProt accession no.

greener alternative category

shipped in


storage temp.


target post-translational modification


Gene Information

human ... GAP43(2596)

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purified antibody

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species reactivity

mouse, rat, human

species reactivity

mouse, human

species reactivity

human, mouse, rat


1D6, recombinant monoclonal


1D4, recombinant monoclonal


4F22, recombinant monoclonal


1G7, monoclonal, recombinant monoclonal

Gene Information

human ... GAP43(2596)

Gene Information

human ... PRPH(5630)

Gene Information

human ... YAP1;YAP65(10413)

Gene Information

human ... SYP(6855)

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General description

We are committed to bringing you greener alternative products, which adhere to one or more of The 12 Principles of Green Chemistry.This antibody is Preservative-free, produced without the harm or sacrifice of animals and exceptionally stable to allow for ambient shipping and storage if needed and thus aligns with "Waste Prevention", "Designing Safer Chemicals" and "Design for Energy Efficiency". Click here for more information.
ZooMAb antibodies represent an entirely new generation of recombinant monoclonal antibodies.

Each ZooMAb antibody is manufactured using our proprietary recombinant expression system, purified to homogeneity, and precisely dispensed to produce robust and highly reproducible lot-to-lot consistency. Only top-performing clones are released for use by researchers. Each antibody is validated for high specificity and affinity across multiple applications, including its most commonly used application. ZooMAb antibodies are reliably available and ready to ship when you need them.

Learn more about ZooMAb here.


Clone 1D6 is a ZooMAb rabbit recombinant monoclonal antibody that specifically detects human Growth-Associated Protein 43 (GAP43).


GST/His-tagged recombinant fragment corresponding to the first 126 amino acids from the N-terminal half of human Growth-Associated Protein 43 (GAP43).


Anti-GAP43, clone 1D6 ZooMAb, Cat. No. ZRB1220, is a highly specific rabbit recombinant monoclonal antibody that targets Growth-associated protein 43 (GAP43) and has been tested for use Immunocytochemistry, Immunohistochemistry (Paraffin). And Western Blotting.
Immunohistochemistry (Paraffin) Analysis: A 1:100 dilution from a representiatve lot detected GAP43 in human and mouse cerebral cortex tissue sections.

Immunocytochemistry Analysis: A 1:100 dilution from a representiatve lot detected GAP43 in SH-SY5Y cells.

Note: Actual optimal working dilutions must be determined by end user as specimens and experimental conditions may vary.

Target description

Neuromodulin (UniProt: P17677; also known as Axonal membrane protein GAP-43, Growth-associated protein 43, Neural phosphoprotein B-50, pp46) is encoded by the GAP43 gene (Gene ID: 2596) in human. GAP43 is a peripheral membrane protein that is associated with nerve growth. It serves as a common marker of differentiating neurons. It is a major component of the motile "growth cones" that form the tips of elongating axons and plays a role in axonal and dendritic filopodia induction. It is expressed at high levels in neuronal growth cones during development and axonal regeneration. However, it is not fond in dendritic cones. In adult brain, GAP43 is found in high concentration in presynaptic areas where memory formation is thought to occur, such as frontal cortex, limbic system and hippocampus. GAP43 contains an N-terminal lipid binding IQ domain (aa 31-60) that also binds calmodulin. GAP43 is reported to bind calmodulin at low calcium levels and then releases it when calcium levels increase indicating that calmodulin may serve as a negative regulator of GAP43 during periods of low neuronal activity. Protein kinase C-mediated phosphorylation serine 41 is reported to inhibit this interaction and stabilizes actin filaments and promotes growth cone extension. This ZooMAb recombinant monoclonal antibody, generated by our propriety technology, offers significantly enhanced specificity, affinity, reproducibility, and stability over conventional monoclonals.(Ref.: Neve, RL et al., (1998). J. Neurosci. 18(19); 7757-7767).

Physical form

Purified recombinant rabbit monoclonal antibody IgG, lyophilized in PBS with 5% Trehalose, normal appearance a coarse or translucent resin. Contains no biocide or preservatives, such as azide, or any animal by-products. Larger pack sizes provided as multiples of 25 μL.


30 μg/mL after reconstitution at 25 μL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.

Storage and Stability

Recommend storage of lyophilized product at 2-8°C; Before reconstitution, micro-centrifuge vials briefly to spin down material to bottom of the vial; Reconstitute each vial by adding 25 μL of filtered lab grade water or PBS; Reconstituted antibodies can be stored at 2-8°C, or -20°C for long term storage. Avoid repeated freeze-thaws.

Legal Information

ZooMAb is a registered trademark of Merck KGaA, Darmstadt, Germany


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

11 - Combustible Solids




Not applicable


Not applicable

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