Ion Exchange Chromatography Resins
Ion exchange (IEX) chromatography is a commonly used purification method that separates a target molecule from other impurities based on the net surface charge. Our portfolio of anion exchange (AEX) and cation exchange (CEX) resins, with our multi-modal chromatography resins, offers efficient purification solutions for mAbs, vaccines, plasmid DNA, plasma, and other modalities.
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These resins are ideal for efficient downstream purification and contain our proven tentacle ligand technology coupled with rigid base beads. They operate at fast flowrates and maintain high binding capacities, improving productivity by reducing time and manufacturing costs.
Eshmuno® CMX mixed-mode resin provides high selectivity for mAbs, fusion proteins, and ADC purification, as well as separation of low molecular weight impurities and HCPs.
Eshmuno® CP-FT resin efficiently removes mAb aggregates in flow-through mode, resulting in 10 times higher loading capacities as compared to traditional bind/elute CEX chromatography. This enables process intensification while reducing the overall cost for downstream mAb purification.
Eshmuno® CPS resin offers high dynamic binding capacity and separation efficiency of recombinant protein feed streams at elevated salt concentrations. This enables direct loading of high-conductivity feed streams (conductivity ≥10 mS/cm), reducing the need for dilution.
Eshmuno® CPX resin effectively separates mAb monomers from aggregates and other impurities including HCP. It delivers superior dynamic binding capacity and enables high-resolution purification of process intermediates with outstanding productivity.
Eshmuno® HCX resin provides fast, efficient, direct capture of proteins, delivering outstanding performance in typical ion exchange and flow-through applications at higher salt levels.
Eshmuno® S is a strong CEX resin for direct capture of recombinant proteins and fast, efficient mAb purification following protein A capture.
Eshmuno® Q is a strong anion resin, offering superior dynamic binding capacity and outstanding impurity removal in typical anion exchange flow-through applications.
Fractogel® EMD IEX chromatography resins
All Fractogel® EMD resins provide high selectivity coupled with consistent pressure stability, enabling very high throughput and excellent yields. The resin’s high binding capacity, even at high flow rates, saves valuable time and improves process economics. Fractogel® resins are offered in different bead sizes with multiple functional groups to meet a range of purification needs:
Fractogel® strong anion exchangers
- Fractogel® EMD TMAE (S) Resin
- Fractogel® EMD TMAE (M) Resin
- Fractogel® EMD TMAE Hicap (M) Resin
- Fractogel® EMD TMAE Medcap (M) Resin
Fractogel® weak anion exchangers
Fractogel® strong cation exchangers
Fractogel® weak cation exchangers
Support for qualification, risk assessment, and process optimization
Complementing our product portfolio, the Emprove® Program provides three types of dossiers to support different stages of development and manufacturing operations such as qualification, risk assessment, and process optimization. The dossiers consolidate comprehensive product-specific testing data, quality statements, and regulatory information in a readily available format to simplify your compliance needs.
Related Product Resources
- Biochromatography Portfolio
Bulk Resin, Membranes and Prepacked Columns
- Chromatography Purification Selection
Protein A Affinity Chromatography Options
- Eshmuno® CMX Resin
A highly selective mixed mode chromatography resin for difficult to purify mAbs, ADCs and fusion proteins
- Eshmuno® CP‑FT Resin
A cation exchange resin specifically developed for the flow-through removal of aggregates using frontal chromatography
- Eshmuno® CPS
High capacity and salt tolerance for recombinant protein purification
- Eshmuno® CPX
Efficient impurity removal and strong binding capacity at high flow rates
- Eshmuno® HCX Media
New, high salt-tolerant multi-mode chromatography resin
- Eshmuno® S Resin for Superior Downstream mAB Purification
For superior downstream mAB purification
- Eshmuno® Q Resin for Efficient AEX Chromatography
Eshmuno® Q resin is a strong anion exchange (AEX) resin, coupling our renowned tentacle structure with a hydrophilic polyvinyl ether base matrix
- Fractogel® Chromatography Resin
Fractogel® resins consist of synthetic methacrylate based polymeric beads providing excellent pressure stability resulting in high flow rates
- Robocolumn® and Minichrom Chromatography Columns
Small-scale prepacked chromatography columns for rapid process development, method optimization, parameter screening and sample preparation
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