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  • Chiral peptide nucleic acids with a substituent in the N-(2-aminoethy)glycine backbone.

Chiral peptide nucleic acids with a substituent in the N-(2-aminoethy)glycine backbone.

Molecules (Basel, Switzerland) (2012-12-29)
Toru Sugiyama, Atsushi Kittaka
ABSTRACT

A peptide nucleic acid (PNA) is a synthetic nucleic acid mimic in which the sugar-phosphate backbone is replaced by a peptide backbone. PNAs hybridize to complementary DNA and RNA with higher affinity and superior sequence selectivity compared to DNA. PNAs are resistant to nucleases and proteases and have a low affinity for proteins. These properties make PNAs an attractive agent for biological and medical applications. To improve the antisense and antigene properties of PNAs, many backbone modifications of PNAs have been explored under the concept of preorganization. This review focuses on chiral PNAs bearing a substituent in the N-(2-aminoethyl)glycine backbone. Syntheses, properties, and applications of chiral PNAs are described.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Glycine, tested according to Ph. Eur.
Pricing and availability is not currently available.
Supelco
Glycine, Pharmaceutical Secondary Standard; Certified Reference Material
Pricing and availability is not currently available.
USP
Glycine, United States Pharmacopeia (USP) Reference Standard
Pricing and availability is not currently available.
Glycine, European Pharmacopoeia (EP) Reference Standard
Pricing and availability is not currently available.
Sigma-Aldrich
Glycine, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, ≥98.5%
Pricing and availability is not currently available.
Sigma-Aldrich
Glycine, ReagentPlus®, ≥99% (HPLC)
Pricing and availability is not currently available.
Sigma-Aldrich
Glycine, BioXtra, ≥99% (titration)
Pricing and availability is not currently available.
Sigma-Aldrich
Glycine, suitable for electrophoresis, ≥99%
Pricing and availability is not currently available.
SAFC
Glycine
Pricing and availability is not currently available.
Sigma-Aldrich
Glycine, meets analytical specification of Ph. Eur., BP, USP, 99-101% (based on anhydrous substance)
Pricing and availability is not currently available.
Sigma-Aldrich
Glycine, SAJ special grade, ≥99.0%
Pricing and availability is not currently available.
Sigma-Aldrich
Glycine, 99%, FCC
Pricing and availability is not currently available.
Sigma-Aldrich
Glycine, ACS reagent, ≥98.5%
Pricing and availability is not currently available.
Sigma-Aldrich
Glycine, BioUltra, for molecular biology, ≥99.0% (NT)
Pricing and availability is not currently available.