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About This Item
実験式（ヒル表記法）:
C11H15NO
CAS番号:
分子量:
177.24
MDL番号:
UNSPSCコード:
12352100
PubChem Substance ID:
NACRES:
NA.22
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品質水準
アッセイ
97%
mp
144-146 °C (lit.)
官能基
isocyanate
SMILES記法
O=C=NC12C[C@H]3C[C@H](C[C@H](C3)C1)C2
InChI
1S/C11H15NO/c13-7-12-11-4-8-1-9(5-11)3-10(2-8)6-11/h8-10H,1-6H2/t8-,9+,10-,11-
InChI Key
VBHCPGFCIQDXGZ-BIBSGERRSA-N
関連するカテゴリー
詳細
1-Adamantyl isocyanate is an isocyanate derivative.
アプリケーション
1-Adamantyl isocyanate may be used in the preparation of:
- adamantyl-functionalized nanoparticles, via thiol-isocyanate reaction of thiol-modified nanoparticles1 4-[3-(aryl or -cycloalkyl)ureido]butyryl compound
- 4-(3-adamantan-1-yl-ureido)butyric acid, via reaction with 4-aminobutanoic acid in DMF
- 4-(3-adamantan-1-yl-ureido)butyryloxy compound
- 12-(3-adamantan-1-yl-ureido) dodecanoic acid (AUDA)
- adamantyl-phenylsulfonamide ureas
- 1-adamantan-1-yl-3-(hydroxyalkyl)ureas, via reaction with with hydroxyalkylamines
シグナルワード
Danger
危険有害性の分類
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
ターゲットの組織
Respiratory system
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
dust mask type N95 (US), Eyeshields, Gloves
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
375063-BULK:
375063-5G:
375063-VAR:
375063-1G:
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E Jeffrey North et al.
Bioorganic & medicinal chemistry, 21(9), 2587-2599 (2013-03-19)
Out of the prominent global ailments, tuberculosis (TB) is still one of the leading causes of death worldwide due to infectious disease. Development of new drugs that shorten the current tuberculosis treatment time and have activity against drug resistant strains
In-Hae Kim et al.
Journal of medicinal chemistry, 47(8), 2110-2122 (2004-04-02)
The soluble epoxide hydrolase (sEH) is involved in the metabolism of endogenous chemical mediators that play an important role in blood pressure regulation and inflammation. 1,3-Disubstituted ureas are potent inhibitors of sEH that are active both in vitro and in
In-Hae Kim et al.
Journal of medicinal chemistry, 50(21), 5217-5226 (2007-09-27)
Soluble epoxide hydrolase (sEH) is a therapeutic target for treating hypertension and inflammation. 1,3-Disubstituted ureas functionalized with an ether group are potent sEH inhibitors. However, their relatively low metabolic stability leads to poor pharmacokinetic properties. To improve their bioavailability, we
In-Hae Kim et al.
Bioorganic & medicinal chemistry, 15(1), 312-323 (2006-10-19)
The soluble epoxide hydrolase (sEH) plays an important role in the metabolism of endogenous chemical mediators involved in blood pressure regulation and vascular inflammation. 12-(3-Adamantan-1-yl-ureido)-dodecanoic acid (AUDA, 1) is a very active inhibitor of sEH both in vitro and in
Kathrin Isenbügel et al.
Macromolecular rapid communications, 31(24), 2121-2126 (2011-05-14)
Stable nanoparticle vesicles were for the first time prepared from adamantyl- and cyclodextrin (CD)-modified silica nanoparticles forming host-guest interactions in aqueous solution. Adamantyl-functionalized nanoparticles were obtained from thiol-isocyanate reaction of thiol-modified nanoparticles with 1-adamantyl isocyanate. The CD modified silica particles
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