901776

Poly(OEGMA)

hydrazide functionalized, 25 wt% solution in water

• 別名: PEGMA, POEGMA
• 化学式: [CH₂CCH₃(COO(CH₂CH₂O)₈CH₃)]_m[CH₂CHCONHNHCO(CH₂)₄CONHNH₂]_p
• UNSPSCコード: 12162002
• NACRES: NA.23

特性

• 形状: solution
• 分子量: ~20,000 g/mol
• 色: clear colorless to pale yellow
• 官能基: hydrazide
• 保管温度: 2-8°C

詳細

詳細

Poly(oligoethylene glycol methacrylate) (POEGMA), is a comb-shaped, graft copolymer consisting of hydrophilic oligomer PEG chains grafted to a hydrophobic polymethacrylate backbone. POEGMA has been suggested as a viable alternative to poly (ethylene glycol) (PEG) in biological and biomaterial applications. POEGMA has been reported to improve pharmacokinetic properties of protein and peptide conjugates, enhance the stability and gene silencing efficiency of siRNAs, as an anti-fouling surface for biosensors, and eliminate PEG antigenicity. In addition to use in biomolecule-polymer conjugates, PEOGMA has also seen wide spread use in tissue engineering applications, such as hydrogel synthesis. Hydrazide-functionalized POEGMA can be readily used with the corresponding aldehyde-functionalized POEGMA for rapid gelation via reversible hydrazone bond formation. Due to the reversibility of the bond formation and the low viscosity of the precursors, resulting hydrogels can be used as injectable tissue engineering matrices, local drug delivery vehicles for small molecules, or as joint lubricants. In addition, the physical properties of the resulting hydrogels, such as LCST, gelation rates, swelling kinetics, degradation kinetics, and mechanical properties, can all be readily controlled by solution concentration and the ratios of each solution.

調製ノート

This product is provided as a 25 wt% solution in water, ready to be diluted for your specific application. Please see the technical bulletin on the product page for dilution and hydrogel preparation instructions.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable