850185P

08:0 PI(4,5)P2

Avanti Research^™ - A Croda Brand

• 別名: PIP2[4′,5′](8:0/8:0); 110665
• 実験式（ヒル表記法）: C₂₅H₅₈N₃O₁₉P₃
• CAS番号: 852043-37-9
• 分子量: 797.66
• UNSPSCコード: 51191904
• NACRES: NA.25

特性

• 詳細: 1,2-dioctanoyl-sn-glycero-3-phospho-(1′-myo-inositol-4′,5′-bisphosphate) (ammonium salt)
• アッセイ: >99% (TLC)
• フォーム: powder
• 包装: pkg of 1 × 100 μg (with stopper and crimp cap (850185P-100ug)); pkg of 1 × 500 μg (with stopper and crimp cap (850185P-500ug))
• メーカー／製品名: Avanti Research^™ - A Croda Brand
• 脂質タイプ: cardiolipins; phospholipids
• 輸送温度: dry ice
• 保管温度: −20°C
• SMILES記法: [H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](OP(O)([O-])=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@H]1O)=O)(OC(CCCCCCC)=O)COC(CCCCCCC)=O.[NH4+].[NH4+].[NH4+]
• InChI: 1S/C25H49O19P3.3H3N/c1-3-5-7-9-11-13-18(26)39-15-17(41-19(27)14-12-10-8-6-4-2)16-40-47(37,38)44-23-20(28)21(29)24(42-45(31,32)33)25(22(23)30)43-46(34,35)36;;;/h17,20-25,28-30H,3-16H2,1-2H3,(H,37,38)(H2,31,32,33)(H2,34,35,36);3*1H3/t17-,20-,21+,22+,23-,24-
• InChI Key: FRWPUPUJRUQWKA-OZTQGENFSA-N

詳細

詳細

Although PI(4,5)P2 is a minor component of cell membranes, it plays a critical role as a substrate for a number of important signaling proteins. PI(4,5)P2 is an intermediate in the IP3/DAG pathway where it is hydrolyzed by phospholipase C to liberate the second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI(4,5)P2 is also a substrate for PI 3-kinase where it is phosphorylated to PI(3,4,5)P3, an activator of downstream signaling components such as the protein kinase AKT. The dioctanoyl derivative of PI(4,5)P2 is more water soluble than its long chain counterparts.

アプリケーション

08:0 PI(4,5)P2 is suitable for use to identify its binding site in transient receptor potential vanilloid 4 (TRPV4 N) terminus. It has been used in in vitro binding assay to determine the binding of G-protein coupled receptor kinases (GRKs) and β2-adrenergic receptor (β₂AR).

包装

2 mL Amber Serum Vial with Stopper and Crimp Cap (850185P-100ug)

2 mL Amber Serum Vial with Stopper and Crimp Cap (850185P-500ug)

法的情報

Avanti Research is a trademark of Avanti Polar Lipids, LLC

安全性情報

• 保管分類コード: 11 - Combustible Solids