D-045

Doxylamine succinate solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

• 実験式（ヒル表記法）: C₂₁H₂₈N₂O₅
• CAS番号: 562-10-7
• 分子量: 388.46
• EC Number: 200-659-6
• MDL番号: MFCD00056168
• UNSPSCコード: 41116107
• NACRES: NA.24

特性

• グレード: certified reference material
• 品質水準: 300
• フォーム: liquid
• 特徴: Snap-N-Spike^®/Snap-N-Shoot^®
• 包装: ampule of 1 mL
• メーカー／製品名: Cerilliant^®
• 濃度: 1.0 mg/mL in methanol (as free base)
• テクニック: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• アプリケーション: pharmaceutical (small molecule)
• フォーマット: single component solution
• 保管温度: −20°C
• SMILES記法: OC(=O)CCC(O)=O.CN(C)CCOC(C)(c1ccccc1)c2ccccn2
• InChI: 1S/C17H22N2O.C4H6O4/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16;5-3(6)1-2-4(7)8/h4-12H,13-14H2,1-3H3;1-2H2,(H,5,6)(H,7,8)
• InChI Key: KBAUFVUYFNWQFM-UHFFFAOYSA-N
• 遺伝子情報: human ... HRH1(3269)

詳細

詳細

Doxylamine is a member of the ethanolamine class of antihistamines and is the most effective over-the-counter (OTC) sedative in the US. This Snap-N-Spike^® Reference Solution is applicable to use in LC/MS or GC/MS applications for clinical toxicology or forensic analysis.

アプリケーション

• Quality assessment of doxylamine succinate: A chemometric approach was applied for quality assessment of doxylamine succinate with its degradation product, using predictive models based on UV-spectrophotometric data, highlighting its utility in ensuring the integrity of pharmaceutical formulations (Abd El-Hadi et al., 2022).


• Analysis in over-the-counter medications: Doxylamine succinate was analyzed as part of a quaternary mixture in cold medications, utilizing a sequential spectrophotometric resolution approach, indicating its role in multi-component pharmaceutical analysis (Kelani et al., 2023).


• LC-MS/MS method for plasma levels: A sensitive LC-MS/MS method was developed for determining doxylamine levels in human plasma, demonstrating its application in pharmacokinetic studies and bioequivalence assessments (Fu et al., 2022).

法的情報

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS02,GHS06,GHS08
• シグナルワード: Danger
• 危険有害性情報: H225,H301 + H311 + H331,H370
• 注意書き: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• 危険有害性の分類: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• ターゲットの組織: Eyes,Central nervous system
• 保管分類コード: 3 - Flammable liquids
• WGK: WGK 2
• 引火点(°F): 49.5 °F - closed cup
• 引火点(℃): 9.7 °C - closed cup