138001

D-Amino Acid Oxidase Inhibitor II, CBIO

The D-Amino Acid Oxidase Inhibitor II, CBIO, also referenced under CAS 61977-29-5, controls the biological activity of D-Amino Acid Oxidase.

• 別名: D-Amino Acid Oxidase Inhibitor II, CBIO, 6-Chloro-1,2-benzisoxazol-3(2H)-one, 6-Chlorobenzo[d]isoxazol-3-ol, D-AAO Inhibitor II, CBIO
• 実験式（ヒル表記法）: C₇H₄ClNO₂
• CAS番号: 61977-29-5
• 分子量: 169.57
• MDL番号: MFCD00125033
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥97% (HPLC)
• フォーム: powder
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: off-white
• 溶解性: DMSO: 50 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• SMILES記法: Clc1cc2[o][nH][c](c2cc1)=O
• InChI: 1S/C7H4ClNO2/c8-4-1-2-5-6(3-4)11-9-7(5)10/h1-3H,(H,9,10)
• InChI Key: SJAPSPJRTQCDNO-UHFFFAOYSA-N

詳細

詳細

A cell-permeable benzisoxazolone compound that potently inhibits D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) activity (IC₅₀ = 90 and 150/188 nM against rat spinal cord and porcine kidney DAO, respectively) in a reversible and D-serine-competitive (K_i = 100 nM) manner. Upon co-administration, CBIO (30 mg/kg, p.o.) markedly prolongs the half-life of orally administered D-serine (30 mg/kg) in plasma, resulting in enhanced rat brain D-serine level (60% vs. 25% above basal, respectively, with vs. without CBIO). Direct intrathecal/spinal CBIO injection either before (ED₅₀ =60 ng) or after (ED₅₀ = 170 ng) subcutaneous formalin injection (50 µl 5% solution) greatly alleviates formalin-induced late phase tonic pain (E_max =67%), but not early phase acute nociception in rats in vivo.

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

It is recommended to prepare a stock solution for 6 month use each time and store the unreconstituted material in solid form, protected from moisture and preferably under inert gas, for best long-term stability during storage.

その他情報

Gong, N., et al. 2011. J. Pharmacol. Exp. Ther.336, 282.
Ferraris, D., et al. 2008. J. Med. Chem.51, 3357.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS05,GHS07
• シグナルワード: Danger
• 危険有害性情報: H302,H315,H318,H335
• 注意書き: P261 - P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable