324897

eIF-2α Inhibitor, Salubrinal

InSolution, ≥95%

• 別名: InSolution eIF-2α Inhibitor, Salubrinal, N-(2,2,2-Tichloro-1-(3-quinolin-8-ylthioureido)ethyl)cinnamamide
• 実験式（ヒル表記法）: C₂₁H₁₇Cl₃N₄OS
• CAS番号: 304475-63-6
• 分子量: 479.81
• MDL番号: MFCD00548612
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: liquid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• 輸送温度: dry ice
• 保管温度: −70°C
• SMILES記法: S=C(NC(NC(/C=C/C1=CC=CC=C1)=O)C(Cl)(Cl)Cl)NC2=CC=CC3=C2N=CC=C3

詳細

詳細

A cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to offer protection against ER stress-induced apoptosis (EC₅₀ ~15 µM in PC12 cells stimulated with 750 ng/ml of Tunicamycin (Cat. No. 654380). Prevents HSV replication both in Vero cells (IC₅₀ ~3 µM for reducing plaque formation) in vitro and in a mouse cornea infection model in vivo. The solid form of this compound (Cat. No. 324895) is also available.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
eIF-2α

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

物理的形状

A 50 mM (5 mg/208 µL) solution of eIF-2α Inhibitor, Salubrinal (Cat. No. 324895) in DMSO.

再構成

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.

その他情報

Boyce, M., et al. 2005. Science307, 935.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): 188.6 °F - closed cup - (refers to pure substance)
• 引火点(℃): 87 °C - closed cup - (refers to pure substance)