343290

Fluoxetine hydrochloride

≥98% (HPLC), solid, selective serotonin re-uptake inhibitor, Calbiochem

• 別名: Fluoxetine, Hydrochloride, dl-N-Methyl-3-( p-trifluoromethylphenoxy)-3-phenylpropylamine, HCl, (±)-N-Methyl-3-phenyl-3-[(α,α,α-trifluoro- p-tolyl)oxy]propylamine, HCl, LY-110140, Prozac
• 実験式（ヒル表記法）: C₁₇H₁₈F₃NO
• CAS番号: 56296-78-7
• 分子量: 309.33
• MDL番号: MFCD00214288
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• product name: Fluoxetine, Hydrochloride, A cell-permeable phenylpropylamine derived anti-depressant that acts as a selective serotonin re-uptake inhibitor (SSRI).
• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic); protect from light
• 溶解性: methanol: 100 mg/mL; water: 5 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• InChI: 1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H
• InChI Key: GIYXAJPCNFJEHY-UHFFFAOYSA-N

詳細

詳細

A cell-permeable phenylpropylamine derived anti-depressant that acts as a selective serotonin re-uptake inhibitor (SSRI). Reported to modulate the proliferation of T cells by increasing the Ca²⁺ influx thereby influencing the activities of protein kinase A (PKA) and protein kinase C (PKC). Inhibits leak K⁺ currents in a reversible and voltage-independent manner (IC₅₀ = 780 nM). Also shown to regulate the phosphorylation of DARPP-32 (dopamine-and cAMP-regulated phosphoprotein of Mr 32,000) and AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors. Triggers oxidative stress-induced apoptotic cell death and initiates signaling pathways in neuronal cells leading to an activation of ERK and NF-κB.

A cell-permeable phenylpropylamine derived anti-depressant that acts as a selective serotonin re-uptake inhibitor (SSRI). Reported to modulate the proliferation of T-cells by increasing the Ca²⁺ influx and thereby influencing the activities of protein kinase A (PKA) and protein kinase C (PKC). Also shown to regulate the phosphorylation of DARPP-32 (dopamine-and cAMP-regulated phosphoprotein of M_r 32,000) and AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors. Shown to trigger oxidative stress-induced apoptotic cell death. Also reported to initiate signaling pathways in neuronal cells leading to activation of ERK and NF-κB.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
Selective serotonin re-uptake inhibitor

Product does not compete with ATP.

Reversible: no

包装

Packaged under inert gas

警告

Toxicity: Harmful (C)

再構成

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Bartholoma, P., et al. 2002. Biochem. Pharmacol.63, 1507.
Bian, J.T., et al. 2002. Eur. J. Pharmacol.453, 159.
Zhang, A., et al. 2002. J. Med. Chem.45, 1930.
Svenningsson, P., et al. 2002. Proc. Natl. Acad. Sci. USA99, 3182.
Edgar, V.A., et al. 1999. Eur. J. Pharmacol.372, 65.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS08,GHS05,GHS07,GHS09
• シグナルワード: Danger
• 危険有害性情報: H302,H318,H336,H373,H410
• 注意書き: P260 - P273 - P280 - P301 + P312 - P305 + P351 + P338 - P314
• 危険有害性の分類: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - STOT RE 2 - STOT SE 3
• ターゲットの組織: Central nervous system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable