369075

Guanidine Hydrochloride

ULTROL^® Grade, ≥99% (titration), protein denaturant for purification of proteins, nucleic acids, and mRNA

• 別名: Guanidinium chloride
• 実験式（ヒル表記法）: CH₅N₃ · xHCl
• CAS番号: 50-01-1
• 分子量: 59.07 (free base basis)
• MDL番号: MFCD00013026
• UNSPSCコード: 12352107
• NACRES: NA.25

特性

• 品質水準: 100
• アッセイ: ≥99% (titration)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic)
• 色: white
• 溶解性: ethanol: soluble; water: soluble
• 輸送温度: ambient
• 保管温度: 15-25°C
• InChI: 1S/CH5N3.ClH/c2-1(3)4;/h(H5,2,3,4);1H
• InChI Key: PJJJBBJSCAKJQF-UHFFFAOYSA-N

詳細

詳細

A powerful protein denaturant that is widely used in the purification of proteins, nucleic acids, and mRNA. It is used in a variety of applications, including sequencing, molecular weight determinations, and as a solubilizing agent for electrophoresis.

Absorbance (6.0 M, H₂O): <0.2 at 230 nm; <0.03 at 260 nm.

アプリケーション

• Revealing the Roles of Guanidine Hydrochloride Ionic Liquid in Ion Inhibition and Defects Passivation for Efficient and Stable Perovskites Solar Cells: Discusses how guanidine hydrochloride ionic liquid enhances the efficiency and stability of perovskite solar cells by ion inhibition and defect passivation (Saeed A et al., 2024).


• N-Fluorosulfonyl Guanidine: An Entry to N-Guanyl Sulfamides and Sulfamates: Investigates the use of N-fluorosulfonyl guanidine for synthesizing N-guanyl sulfamides and sulfamates, showcasing its potential in chemical synthesis and material science (Wang W et al., 2024).


• Efficient extraction of lignin from moso bamboo by microwave-assisted ternary deep eutectic solvent pretreatment for enhanced enzymatic hydrolysis: Explores the role of guanidine hydrochloride in enhancing the enzymatic hydrolysis of lignin extracted from moso bamboo using a microwave-assisted deep eutectic solvent method (Feng Y et al., 2024).


• Computational Enzyme Redesign Enhances Tolerance to Denaturants for Peptide C-Terminal Amidation: Details how computational redesign of enzymes, involving guanidine hydrochloride, can enhance their tolerance to denaturants, improving the efficiency of peptide C-terminal amidation processes (Zhu T et al., 2024).


• Parasite Burden of Trypanosoma cruzi in Whole Blood and Buffy Coat Determined by Real-Time PCR in Individuals with Chronic Chagas Disease: Describes the use of guanidine hydrochloride in real-time PCR processes to quantify the parasite burden in blood samples from individuals with Chagas disease, demonstrating its utility in enhancing diagnostic assays (Liempi D et al., 2024).

警告

Toxicity: Harmful (C)

その他情報

Bastiras, S., and Wallace, J.C. 1992. Biochemistry31, 9304.
Plaza del Pino, I.M., et al. 1992. Biochemistry31, 11196.
Steinman, H., et al. 1974. J. Biol. Chem.249, 7326.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

ULTROL is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302 + H332,H315,H319
• 注意書き: P261 - P264 - P301 + P312 - P302 + P352 - P304 + P340 + P312 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable