401020

Imiquimod

An imidazoquinoline compound that acts as a potent immunomodulator and displays anti-angiogenic, anti-viral and anti-inflammatory properties.

• 別名: Imiquimod, 1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine
• 実験式（ヒル表記法）: C₁₄H₁₆N₄
• CAS番号: 99011-02-6
• 分子量: 240.30
• MDL番号: MFCD00866946
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: DMSO: 3 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• InChI: 1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17)
• InChI Key: DOUYETYNHWVLEO-UHFFFAOYSA-N

詳細

詳細

An imidazoquinoline compound that acts as a potent immunomodulator and displays anti-angiogenic, anti-viral and anti-inflammatory properties. Reported to bind to the cell surface receptor, TLR7 (toll-like receptor 7), and induce the secretion of several pro-inflammatory cytokines and chemokines both in vitro and in vivo.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
TLR7 (toll-like receptor 7)

Product does not compete with ATP.

Reversible: no

包装

Packaged under inert gas

警告

Toxicity: Toxic (F)

調製ノート

warming to 60°C is required for complete solubilization.

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Upon thawing, warming may be required to resolubilize precipitated product.

その他情報

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Majewski, S., et al. 2005. Int. J. Dermatol.44, 14.
Gibson, S.J., et al. 2002. Cell. Immunol.218, 74.
Hemmi, H., et al. 2002. Nat. Immunol.3, 196.
Megyeri, K., et al. 1995. Mol. Cell. Biol.15, 2207.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H301,H315,H319
• 注意書き: P264 - P270 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2
• 保管分類コード: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable