5.06271

Ketanserin Tartrate

• 別名: Ketanserin Tartrate, 5-HT _2A Serotonin Receptor Antagonist, Ketanserin, R 41 468
• 実験式（ヒル表記法）: C₂₂H₂₂FN₃O₃ · xC₄H₆O₆
• CAS番号: 83846-83-7
• 分子量: 395.43 (free base basis)
• MDL番号: MFCD00084651
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥97% (HPLC)
• 品質水準: 100
• フォーム: solid
• 有効性: 1.49 nM K_i
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: DMSO: soluble
• 保管温度: 2-8°C
• SMILES記法: Fc1ccc(cc1)C(=O)C2CCN(CC2)CCN3C(=O)Nc4c(cccc4)C3=O.OC(C(O)C(=O)O)C(=O)O.O
• InChI: 1S/C22H22FN3O3.C4H6O6.H2O/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29;5-1(3(7)8)2(6)4(9)10;/h1-8,16H,9-14H2,(H,24,29);1-2,5-6H,(H,7,8)(H,9,10);1H2
• InChI Key: KJJRKCWDAHTVRL-UHFFFAOYSA-N

詳細

詳細

A selective 5-HT_2A serotonin receptor antagonist with weak adrenergic receptor blocking properties. Strong affinity for 5-HT_2AR (K_i = 1.49 nM) relative to other family members like 5-HT_2BR (K_i = 740 nM) and 5-HT_2CR (K_i = 59 nM). Often used in conjunction with SB 206553 to distinguish 5-HT_2AR and 5-HT_2CR activity.

生物化学的／生理学的作用

Primary Target
5-HT_2A

警告

Toxicity: Toxic (F)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Ros, R. et al. 2013. PNAS.110, 348.

Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114.
Aloyo, V. J. and Harvey, J. A. 2000. Eur. J. Pharmacol.406, 163.
Leysen, J. E. et al. 1981. Life Sci.28, 1015.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H301
• 注意書き: P264 - P270 - P301 + P310 - P405 - P501
• 危険有害性の分類: Acute Tox. 3 Oral
• 保管分類コード: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable