528110-M

PIH

A cell-permeable, non-toxic tridendate iron (Fe3+) chelator of the aroyl hydrazone class.

• 別名: PIH, pyridoxal isonicotinoyl hydrazone, Iron Chelator III
• 実験式（ヒル表記法）: C₁₄H₁₄N₄O₃
• CAS番号: 737-86-0
• 分子量: 286.29
• MDL番号: MFCD00763290
• UNSPSCコード: 12352200
• NACRES: NA.28

特性

• 品質水準: 100
• アッセイ: ≥99% (HPLC)
• フォーム: solid
• 反応適合性: reagent type: chelator
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: yellow
• 溶解性: DMSO: 5 mg/mL; slighlty acidic medium: soluble
• 保管温度: 2-8°C
• InChI: 1S/C14H14N4O3/c1-9-13(20)12(11(8-19)6-16-9)7-17-18-14(21)10-2-4-15-5-3-10/h2-7,17,19H,8H2,1H3,(H,18,21)/b12-7+
• InChI Key: HOYFGBFEIXEDEL-KPKJPENVSA-N

詳細

詳細

A cell-permeable, non-toxic tridendate iron (Fe³⁺) chelator of the aroyl hydrazone class. Even at low concentrations, highly effective in mobilizing Fe³⁺ from cells and preventing its uptake from transferrin, even at low concentrations. Exhibits similar specificity and binding affinity as Deferoxamine Mesylate (Cat. No. 252750) but has greater access to mitochondrial iron. Also useful for the management of iron overload disease in experimental models. Inhibits the induction of heme containing indoleamine 2,3-dioxygenase activity.

A cell-permeable, non-toxic, iron (Fe³⁺) chelator of the aroyl hydrazone class that exhibits high chelation efficacy. Highly effective in mobilizing Fe³⁺ from cells and preventing its uptake from transferrin, even at low concentrations. Exhibits similar specificity and binding affinity as Desferrioxamine (Cat. No. 252750) but has greater access to mitochondrial iron. Prevents iron-mediated oxyradical formation and minimizes tissue damage. Reported to useful in studies of the management of iron overload disease. Inhibits the induction of heme-containing indoleamine 2,3-dioxygenase activity.

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. Acidic stock solutions are stable for up to 2 months at -20°C.

その他情報

Buss, J.L., et al. 2002. Biochem. Pharmacol.64, 1689.
Thomas, S.R., et al. 2001. J. Immunol.166, 6332.
Hermes-Linda, M., et al. 2000. Biochim. Biophys. Acta1523, 154.
Blaha, K., et al. 1998. Blood11, 4368.
Richardson, D.R., and Ponka, P. 1998. J. Lab. Clin. Med.131, 306.
Richardson, D.R.,et al. 1995. Blood86, 4295.
Richardson, D.R., et al. 1994. J. Lab. Clin. Med.124, 660.
Ponka, P., et al. 1988. Biochim. Biophys. Acta967, 122.
Ponka, P., et al. 1984. Biochim. Biophys. Acta802, 477.
Ponka, P., et al. 1979. FEBS Lett.97, 317.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable