539160

Proteasome Inhibitor I

The Proteasome Inhibitor I controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• 別名: Proteasome Inhibitor I, PSI
• 実験式（ヒル表記法）: C₃₂H₅₀N₄O₈
• 分子量: 618.76
• UNSPSCコード: 12352202
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥90% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 色: white
• 溶解性: DMSO: 30 mg/mL; ethanol: 30 mg/mL; methanol: soluble
• 輸送温度: ambient
• 保管温度: −20°C

詳細

詳細

A cell-permeable, reversible inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (MCP; 20S proteasome) in HT4 cells. Causes the accumulation of ubiquitinated proteins in neuronal cells. Prevents the activation of NF-κB in response to TNF-α and Okadaic Acid (Cat. No. 495604) through inhibition of IκB-α degradation. A 50 mM (5 mg/162 µl) solution of Proteasome Inhibitor I (Cat. No. 539161) in DMSO is also available.

Cell-permeable inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (MCP; 20S proteasome) in HT4 cells. Causes the accumulation of ubiquitinylated proteins in neuronal cells. Prevents NF-κB activation in response to TNFα and okadaic acid through inhibition of IκB-α degradation, thereby interfering with induction of iNOS in macrophages.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
Chymotrypsin-like activity of the multicatalytic proteinase complex (MCP; 20S proteasome) in HT4 cells

Product does not compete with ATP.

Reversible: yes

警告

Toxicity: Standard Handling (A)

シーケンス

Z-Ile-Glu(OtBu)-Ala-Leu-CHO

再構成

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C.

その他情報

Griscavage, J.M., et al. 1996. Proc. Natl. Acad. Sci. USA93, 3308.
Mori, S., et al. 1995. J. Biol. Chem.270, 29447.
Figueiredo-Pereira, M.E., et al. 1994. J. Neurochem. 63, 1578.
Traenckner, E.B., et al. 1994. EMBO J. 13, 5433.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable