474788

MG-132

≥95% (HPLC), liquid, proteasome inhibitor, Calbiochem^®

• 別名: InSolution MG-132 in EtOH, ≥95% by HPLC, Proteasome Inhibitor XI
• 実験式（ヒル表記法）: C₂₆H₄₁N₃O₅
• 分子量: 475.62
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• product name: MG-132 in EtOH, ≥95% by HPLC, InSolution, ≥95%, reversible proteasome inhibitor
• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: liquid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; avoid repeated freeze/thaw cycles; protect from light
• 輸送温度: ambient
• 保管温度: −70°C

詳細

詳細

Potent, reversible, and cell-permeable proteasome inhibitor (K_i = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-κB activation (IC₅₀ = 3 µM). This material is ≥95% pure by HPLC. A material with ≥98% purity by HPLC (Cat. No. 474791) is also available.

Potent, reversible, and cell-permeable proteasome inhibitor (K_i = 4 nM).Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-κBactivation (IC₅₀ = 3 µM). This material is ≥95% pure by HPLC. A material with ≥98% purity by HPLC (Cat. No. 474791) and the solid form of this compound (Cat. No. 474787) are also available.

生物化学的／生理学的作用

Cell permeable: yes

K_i = 4 nM for proteasomal inhibition

Reversible: yes

Secondary Target
IKK

包装

Packaged under inert gas

警告

Toxicity: Flammable (J)

物理的形状

A 20 mM (10 mg/1.05 ml) solution of MG-132, ≥95% by HPLC (Cat. No. 474787) in EtOH.

再構成

Following initital thaw, aliquot and freeze (-70°C).

その他情報

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS02,GHS07
• シグナルワード: Danger
• 危険有害性情報: H225,H319
• 注意書き: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Flam. Liq. 2
• 保管分類コード: 3 - Flammable liquids
• WGK: WGK 2
• 引火点(°F): 53.6 °F - closed cup - Information refers to the main ingredient.
• 引火点(℃): 12 °C - closed cup - Information refers to the main ingredient.