551600-M

Quercetin, Dihydrate

A cell-permeable and reversible inhibitor of PIM1 kinase (IC₅₀ = 43 nM), PI 3-K (IC₅₀ = 3.8 µM) and phospholipase A2 (IC₅₀ = 2 µM).

• 別名: Quercetin, Dihydrate, 3,3ʹ,4ʹ,5,7-Pentahydroxyflavone
• 実験式（ヒル表記法）: C₁₅H₁₀O₇ · 2H₂O
• CAS番号: 6151-25-3
• 分子量: 338.27
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: >95% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: yellow
• 溶解性: acetic acid: 1 mg/mL; aqueous base: 1 mg/mL; DMSO: 5 mg/mL
• 保管温度: 10-30°C
• InChI: 1S/C15H10O7.2H2O/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6;;/h1-5,16-19,21H;2*1H2
• InChI Key: GMGIWEZSKCNYSW-UHFFFAOYSA-N

詳細

詳細

A cell-permeable and reversible inhibitor of PIM1 kinase (IC₅₀ = 43 nM), PI 3-K (IC₅₀ = 3.8 µM) and phospholipase A₂ (IC₅₀ = 2 µM). Also inhibits mitochondrial ATPase, phosphodiesterases, and protein kinase C. Induces apoptosis in K562, Molt-4, Raji, and MCAS tumor cell lines. Reported to activate sirtuins and promote the survival of eukaryotic cells.

A cell-permeable inhibitor of PIM1 kinase (IC₅₀ = 43 nM), PI 3-K (IC₅₀ = 3.8 µM) and phospholipase A₂ (IC₅₀ = 2 µM). Also inhibits mitochondrial ATPase, phosphodiesterases, and protein kinase C. Induces apoptosis in K562, Molt-4, Raji, and MCAS tumor cell lines. Reported to activate sirtuins and promote the survival of eukaryotic cells.

生物化学的／生理学的作用

Primary Target
PI 3-kinase

Target IC₅₀: 43 nM, 3.8 µM, 2 µM against PIM1 kinase, PI 3-K, and phospholipase A2, respectively

警告

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

その他情報

Bullock, A.N., et al. 2005. J. Med. Chem.48, 7604.
Howitz, K.T., et al. 2003. Nature425, 191.
Wei, Y.Q., et al. 1994. Cancer Res.54, 4952.
Shibasaki, F., et al. 1993. Biochem. J.289, 227.
Matter, W.F., et al. 1992. Biochem. Biophys. Res. Comm.186, 624.
Levy, J., et al. 1984. Biochem. Biophys. Res. Commun.123, 1227.
Graziani, Y., et al. 1983. Eur. J. Biochem.135, 583.
Gschwendt, M., et al. 1983. Biochem. Biophys. Res. Commun. 117, 444.
Ruckstuhl, M., et al. 1979. Biochem. Pharmacol.28, 535.
Beretz, A., et al. 1978. Experientia 34, 1054.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H301
• 注意書き: P264 - P270 - P301 + P310 - P405 - P501
• 危険有害性の分類: Acute Tox. 3 Oral
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 1