565784-M

γ-Secretase Inhibitor IX

≥95% (HPLC), liquid, γ-secretase inhibitor, Calbiochem^®

• 別名: InSolution γ-Secretase Inhibitor IX, N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester, DAPT
• 実験式（ヒル表記法）: C₂₃H₂₆F₂N₂O₄
• 分子量: 432.46
• UNSPSCコード: 12352200

特性

• product name: γ-Secretase Inhibitor IX, InSolution, ≥95%, 25 mM, g-secretase Inhibitor IX
• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: liquid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic); protect from light
• 色: clear colorless
• 保管温度: 2-8°C

詳細

詳細

A cell-permeable dipeptide that inhibits γ-secretase activity and suppresses Aβ production (Aβ total IC₅₀ = 115 nM; Aβ₄₂ IC₅₀ = 200 nM). Reported to be functionally active in both HEK293 cells overexpressing human APP751 and neuronal cultures, however, it does not affect the secretion of amyloid-b precursor protein (APP). Effective in acutely lowering Ab in APPV717F-transgenic mice. Also effective in inhibiting the production of a ~6 kDa C-terminal cleavage product (CTFg) in HEK293 cells stably transfected with the Swedish mutant, βAPP₆₉₅. Reported to reduce extracellular Aβ plaques and intracellular Aβ accumulation in 3xTgAD transgenic mice.

生物化学的／生理学的作用

Primary Target
Aβ_total

Target IC₅₀: 115 nM, 200 nM against Aβ_total, Aβ42, respectively

警告

Toxicity: Irritant (B)

物理的形状

A 25 mM (5 mg/462 µl or 10 mg/924 µl) solution of γ-Secretase Inhibitor IX (Cat. No. 565770) in DMSO.

再構成

Following initial use, aliquot and freeze (-20°C).

その他情報

Oddo, S., et al. 2004. Neuron43, 321.
Dovey, H.F., et al. 2001. J. Neurochem.76, 173.
Vandermeeren, M., et al. 2001. Neurosci. Lett.315, 145.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): 188.6 °F - closed cup - (refers to pure substance)
• 引火点(℃): 87 °C - closed cup - (refers to pure substance)