8.18586

Isophorone diisocyanate

(mixture of cis- and trans-isomers) for synthesis

• 別名: Isophorone diisocyanate, 5-Isocyanato-1-isocyanatomethyl-1,3,3-trimethylcyclohexane, 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate
• 実験式（ヒル表記法）: C₁₂H₁₈N₂O₂
• CAS番号: 4098-71-9
• 分子量: 222.28
• MDL番号: MFCD00064956
• UNSPSCコード: 12352118
• EC Index Number: 223-861-6
• NACRES: NA.22

特性

• 蒸気圧: 0.0004 hPa ( 20 °C)
• 品質水準: 200
• アッセイ: ≥99.0% (GC)
• 形状: liquid
• 自己発火温度: 430 °C
• 有効性: 4825 mg/kg LD₅₀, oral (Rat); >7000 mg/kg LD₅₀, skin (Rat)
• expl. lim.: 0.7-4.5 % (v/v)
• bp: 158-159 °C/13 hPa
• mp: -60 °C
• 転移温度: flash point 155 °C
• 溶解性: 0.015 g/L (slow decomposition)
• 密度: 1.06 g/cm³ at 20 °C
• 保管温度: 2-30°C
• InChI: 1S/C12H18N2O2/c1-11(2)4-10(14-9-16)5-12(3,6-11)7-13-8-15/h10H,4-7H2,1-3H3
• InChI Key: NIMLQBUJDJZYEJ-UHFFFAOYSA-N

詳細

アプリケーション

• Thermoresponsive Random Poly(ether urethanes) with Tailorable LCSTs for Anticancer Drug Delivery.: This study explores the development of thermoresponsive random poly(ether urethanes) synthesized using Isophorone diisocyanate. These polymers exhibit adjustable lower critical solution temperatures (LCSTs), making them suitable for controlled anticancer drug delivery applications. The research highlights the potential of Isophorone diisocyanate in creating advanced materials for medical use, specifically in drug delivery systems (Sardon et al., 2015).

アナリシスノート

Assay (GC, area%): ≥ 99.0 % (a/a)
Density (d 20 °C/ 4 °C): 1.060 - 1.062
Identity (IR): passes test

安全性情報

• ピクトグラム: GHS06,GHS08,GHS09
• シグナルワード: Danger
• 危険有害性情報: H315 - H317 - H319 - H330 - H334 - H335 - H411
• 注意書き: P260 - P273 - P280 - P302 + P352 - P304 + P340 + P310 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 1 Inhalation - Aquatic Chronic 2 - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 2
• 引火点(°F): 325.4 °F - closed cup
• 引火点(℃): 163 °C - closed cup