8.51009

PyBOP^®

Novabiochem^®

• 別名: Benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluorophosphate, PyBOP^®
• 実験式（ヒル表記法）: C₁₈H₂₈N₆OP · F₆P
• CAS番号: 128625-52-5
• 分子量: 520.39
• MDL番号: MFCD00077411
• UNSPSCコード: 12352107
• NACRES: NA.22

特性

• 品質水準: 400
• 製品種目: Novabiochem^®
• アッセイ: ≥99.0% (HPLC)
• 形状: powder
• 反応適合性: reaction type: Coupling Reactions
• メーカー／製品名: Novabiochem^®
• 環境により配慮した代替製品の特徴: Less Hazardous Chemical Syntheses; Learn more about the Principles of Green Chemistry.
• mp: 140-155 °C
• アプリケーション: peptide synthesis
• 環境により配慮した代替製品カテゴリ: Aligned
• 保管温度: 2-8°C
• InChI: 1S/C18H28N6OP/c1-2-10-18-17(9-1)19-20-24(18)25-26(21-11-3-4-12-21,22-13-5-6-14-22)23-15-7-8-16-23/h1-2,9-10H,3-8,11-16H2/q+1
• InChI Key: WGNZRLMOMHJUSP-UHFFFAOYSA-N

詳細

詳細

The standard in situ coupling reagent for solid phase peptide synthesis ^[1,2,3,4,5]. This product can replace BOP in all applications without loss of performance. Unlike uronium-based reagents, PyBOP^® does not give rise to guanidinated by-products during cyclization and fragment condensation reactions.

Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references

^[1] J. Martinez, et al. (1985) J. Med. Chem., 28, 1874.
^[2] J. Coste, et al. (1990) Tetrahedron Lett., 31, 205.
^[3] G. B. Fields, et al. in ′Innovation & Perspectives in Solid Phase Synthesis, 1st International Symposium′, R. Epton (Eds), SPCC UK Ltd., Birmingham, 1990, pp. 241.
^[4] T. Høeg-Jensen, et al. (1991) Tetrahedron Lett., 32, 7617.
^[5] R. von Eggelkraut-Gottanka, et al. (2003) Tetrahedron Lett., 44, 3551.

We are committed to bringing you greener alternative products, which adhere to one or more of the 12 Principles of Green Chemistry. PyBOP is widely used as a substitute for the BOP, with the aim of avoiding formation of hexamethylphosphoric triamide (HMPA) which is a carcinogenic side product. Click here for more information.

関連事項

Replaces: 01-62-0016

アナリシスノート

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble

法的情報

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS07,GHS09
• シグナルワード: Warning
• 危険有害性情報: H302 - H317 - H410
• 注意書き: P261 - P264 - P273 - P280 - P301 + P312 - P302 + P352
• 危険有害性の分類: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Sens. 1
• 保管分類コード: 13 - Non Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable