8.51013

HATU

for peptide synthesis, Novabiochem^®

• 別名: HATU, 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate, N-[(Dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide
• 実験式（ヒル表記法）: C₁₀H₁₅N₆O · F₆P
• CAS番号: 148893-10-1
• 分子量: 380.23
• MDL番号: MFCD27957364
• UNSPSCコード: 12352107
• NACRES: NA.22

特性

• 製品名: HATU, Novabiochem^®
• 品質水準: 300
• 製品種目: Novabiochem^®
• フォーム: solid
• 反応適合性: reaction type: Coupling Reactions
• メーカー／製品名: Novabiochem^®
• mp: 186 °C (decomposes)
• アプリケーション: peptide synthesis
• 保管温度: 2-8°C
• SMILES記法: [n]1(nnc2c1nccc2)[O+]=C(N(C)C)N(C)C
• InChI: 1S/C10H15N6O/c1-14(2)10(15(3)4)17-16-9-8(12-13-16)6-5-7-11-9/h5-7H,1-4H3/q+1
• InChI Key: WXIONIWNXBAHRU-UHFFFAOYSA-N

詳細

詳細

A highly efficient coupling reagent for solid and solution phase peptide synthesis. In comparative studies HATU has been found to give better coupling yields with less enantiomerization that HBTU, TBTU or PyBOP^®[1,2,3]. It is particularly effective at coupling to N-alkyl amines where other coupling reagents give poor yields and is the preferred reagent for loading resins bearing secondary amino groups.

Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references

^[1] L. A. Carpino (1993) J. Am. Chem. Soc., 115, 4397.
^[2] F. Albericio, et al. (1998) J. Org. Chem., 63, 9678.
^[3] J. A. Carpino, et al., in "Innovation & Perspectives in Solid Phase Synthesis, 3rd International Symposium", R. Epton (Ed.), Mayflower Worldwide Ltd., 1994, pp. 95.

関連事項

Replaces: 01-62-0041

アナリシスノート

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Identity (NMR, 1H): passes test
Solubility (1 mmole in 2 ml DMF): clearly soluble

法的情報

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS08
• シグナルワード: Danger
• 危険有害性情報: H317 - H334
• 注意書き: P261 - P272 - P280 - P284 - P302 + P352 - P304 + P340 + P312
• 危険有害性の分類: Resp. Sens. 1 - Skin Sens. 1
• 保管分類コード: 4.1A - Other explosive hazardous materials
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable