14606

コレステロール

tested according to Ph. Eur.

• 別名: コレステロール, 3β-ヒドロキシ-5-コレステン, 5-コレステン-3β-オール
• 実験式（ヒル表記法）: C₂₇H₄₆O
• CAS番号: 57-88-5
• 分子量: 386.65
• Beilstein: 1915888
• EC Number: 200-353-2
• MDL番号: MFCD00003646
• UNSPSCコード: 41141804
• PubChem Substance ID: 329750548
• NACRES: NA.21

特性

• 認証: USP/NF; tested according to Ph. Eur.
• 品質水準: 100
• フォーム: powder
• bp: 360 °C (lit.)
• mp: 147-149 °C (lit.)
• 溶解性: chloroform: soluble 1 gm in 4.5 ml; diethyl ether: soluble 1 gm in 2.8 ml; pyridine: soluble 1 gm in 1.5 ml; H₂O: insoluble; acetone: soluble; alcohol: slightly soluble; alcohol: very soluble (Hot); benzene: soluble; dioxane: soluble; ethyl acetate: soluble; hexane: soluble; oil: soluble; petroleum ether: soluble
• 密度: 1.067 g/mL at 25 °C (lit.)
• アプリケーション: pharmaceutical (small molecule)
• 保管温度: 2-8°C
• SMILES記法: CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
• InChI: 1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
• InChI Key: HVYWMOMLDIMFJA-DPAQBDIFSA-N
• 遺伝子情報: human ... POLA1(5422) , TOP2A(7153) ; rat ... Ar(24208) , Polb(29240)

詳細

アプリケーション

Cholesterol was used for preparing ISCOMS containing ovalbumin (OVA) for studying whether the incorporation of the protein antigen ovalbumin (OVA) in lipophilic immune-stimulating complexes (ISCOMS) induces very strong primary immune responses. It was incorporated in animal feed to study the effect of cholesterol-rich diet.

生物化学的／生理学的作用

Cholesterol is a lipid that makes up about 20-25% of the structural components of the cell membranes. It determines the fluidity and permeability of the membrane, making it permeable to water but not to ions and protons. Cholesterol also regulates the functions of the transporters and signaling proteins present on the plasma membrane. The major sites of cholesterol synthesis are small intestine and liver.

すべての生体膜の主成分。脳脂質全体の約25%はコレステロ-ルです。

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)