N5410

ニコチン酸

meets USP testing specifications

• 別名: 3-ピコリン酸, ナイアシン, ビタミンB₃, ピリジン-3-カルボン酸, ペラグラ予防因子
• 実験式（ヒル表記法）: C₆H₅NO₂
• CAS番号: 59-67-6
• 分子量: 123.11
• Beilstein: 109591
• EC Number: 200-441-0
• MDL番号: MFCD00006391
• UNSPSCコード: 12352106
• PubChem Substance ID: 24897734
• NACRES: NA.21

特性

• 由来生物: synthetic (organic)
• 品質水準: 200
• 認証: USP/NF; meets USP testing specifications
• アッセイ: 99.0-101.0% dry basis
• 形状: powder
• 色: white
• mp: 236-239 °C (lit.)
• アプリケーション: pharmaceutical (small molecule)
• SMILES記法: OC(=O)c1cccnc1
• InChI: 1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
• InChI Key: PVNIIMVLHYAWGP-UHFFFAOYSA-N
• 遺伝子情報: human ... CYP1A2(1544) ; rat ... Chrnb2(54239)

詳細

詳細

Nicotinic acid, also referred to as niacin or as vitamin B₃, is a water-soluble vitamin. Nicotinic acid is synthesized from the amino acid tryptophan and is present majorly in peanuts, fish and lean meat.

アプリケーション

Nicotinic acid has been used as an antioxidant to evaluate its protective functionality in colon LoVo cell lines against doxorubicin induced cytotoxicity.

生物化学的／生理学的作用

Nicotinic modulates lipid metabolism and may be useful in treating dyslipidemia. It is an antioxidant and acts as a coenzyme in the form of nicotinamide adenine nucleotides. Deficiency of niacin leads to enhanced lipid peroxidation and is also implicated in Crohn′s disease Deficiency also impacts DNA repair and also leads to skin and gastrointestinal disorder, pellagra. Nicotinic acid reduces the low-density lipoprotein (LDL) synthesis and improves high-density lipoprotein (HDL) levels.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H319
• 注意書き: P264 - P280 - P305 + P351 + P338 - P337 + P313
• 危険有害性の分類: Eye Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): 379.4 °F - closed cup
• 引火点(℃): 193 °C - closed cup
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves