PHR1524

タムスロシン 塩酸塩

Pharmaceutical Secondary Standard; Certified Reference Material

• 別名: 5-[(2R)-2-[[2-(2-エトキシフェノキシ)エチル]アミノ]プロピル]-2-メトキシベンゼンスルホンアミド塩酸塩
• 実験式（ヒル表記法）: C₂₀H₂₈N₂O₅S · HCl
• CAS番号: 106463-17-6
• 分子量: 444.97
• MDL番号: MFCD00922997
• UNSPSCコード: 41116107
• PubChem Substance ID: 329823437
• NACRES: NA.24

特性

• グレード: certified reference material; pharmaceutical secondary standard
• 品質水準: 300
• 認証: traceable to BP 876; traceable to Ph. Eur. Y0000650; traceable to USP 1643260
• APIファミリー: tamsulosin
• CofA: current certificate can be downloaded
• 包装: ampule of 1 × 200 mg
• テクニック: HPLC: suitable; gas chromatography (GC): suitable
• アプリケーション: pharmaceutical (small molecule)
• フォーマット: neat
• 保管温度: -10 to -25°C
• SMILES記法: Cl.CCOc1ccccc1OCCN[C@H](C)Cc2ccc(OC)c(c2)S(N)(=O)=O
• InChI: 1S/C20H28N2O5S.ClH/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24;/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24);1H/t15-;/m1./s1
• InChI Key: ZZIZZTHXZRDOFM-XFULWGLBSA-N
• 遺伝子情報: human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

詳細

詳細

Tamsulosin hydrochloride is a subtypeselective a₁A and a₁D adrenoceptor antagonist, which exists in two enantiomeric forms, of which the R-isomer is the pharmaceutically active component. It is used to reduce urinary obstruction and is also involved in relieving the symptoms associated with symptomatic benign prostatic hyperplasia.

アプリケーション

Tamsulosin hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生物化学的／生理学的作用

タムスロシンは、前立腺肥大症(BPH)の治療として用いられるα1A/1D-アドレナリン受容体拮抗薬です。本製品のα受容体阻害剤としての活性は虹彩にも影響し、白内障手術中に虹彩緊張低下症候群と呼ばれる合併症を引き起こしています。

脚注

To see an example of a Certificate of Analysis for this material enter LRAC0288 in the slot below. This is an example certificate only and may not be the lot that you receive.

おすすめ製品

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302
• 注意書き: P264 - P270 - P301 + P312 - P501
• 危険有害性の分類: Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable