53300

ヒスタミン 二塩酸塩

≥99.0% (AT), powder or crystals, endogenous histamine receptor agonist

• 別名: 2-(4-イミダゾリル)エチルアミン 二塩酸塩
• 実験式（ヒル表記法）: C₅H₉N₃ · 2HCl
• CAS番号: 56-92-8
• 分子量: 184.07
• Beilstein: 3624116
• EC Number: 200-298-4
• MDL番号: MFCD00012703
• UNSPSCコード: 12352116
• eCl@ss: 32160406
• PubChem Substance ID: 329757931
• NACRES: NA.77

特性

• 製品名: ヒスタミン 二塩酸塩, ≥99.0% (AT)
• アッセイ: ≥99.0% (AT)
• フォーム: powder or crystals
• 強熱残分: ≤0.2%
• 損失: ≤0.2% loss on drying, 20 °C (HV)
• mp: 244-247 °C; 249-252 °C (lit.)
• 溶解性: H₂O: 0.1 g/mL, clear, colorless
• 微量陰イオン: sulfate (SO₄^2-): ≤200 ppm
• 微量陽イオン: Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Zn: ≤5 mg/kg
• SMILES記法: Cl[H].Cl[H].NCCc1c[nH]cn1
• InChI: 1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H
• InChI Key: PPZMYIBUHIPZOS-UHFFFAOYSA-N
• 遺伝子情報: human ... HRH1(3269)

詳細

詳細

Histamine is a hydrophilic amine derived from the decarboxylation of histidine by the enzyme L-histidine decarboxylase. Histamine has been shown to play a role in many physiological processes such as gastric secretion, neurotransmission, immune response, vasodialation, and inflammation. Additionally, studies have reported a role for histamine dihydrochloride with interleukin-2 (IL-2) in treatment of acute myeloid leukemia and in protection against alcohol-induced liver injury in rats.

生物化学的／生理学的作用

内在性のヒスタミン受容体H₁, H₂のアゴニストです。一酸化窒素シンターゼを活性化します。強力な血管拡張剤です。

Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H₂ histamine receptor.

その他情報

Substrate for the assay of histamine-N-methyltransferase (EC 2.1.1.8); Ion-pair extraction of histamine from biological fluids for its determination by HPLC with fluorescence detection

安全性情報

• ピクトグラム: GHS08,GHS07
• シグナルワード: Danger
• 危険有害性情報: H315,H317,H319,H334,H335
• 注意書き: P280 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Faceshields, Gloves