95200

ヒドロキソコバラミン 塩酸塩

≥96% (UV), ≥96% (HPLC)

• 別名: ビタミンB_12a
• 実験式（ヒル表記法）: C₆₂H₈₉CoN₁₃O₁₅P · HCl
• CAS番号: 59461-30-2
• 分子量: 1382.82
• EC Number: 261-772-4
• MDL番号: MFCD00167463
• UNSPSCコード: 12352205
• PubChem Substance ID: 57653658
• NACRES: NA.79

特性

• 由来生物: fermentation/recombinant
• 品質水準: 100
• アッセイ: ≥96% (HPLC); ≥96% (UV)
• フォーム: powder or crystals
• 損失: ≤12% loss on drying, 20 °C (HV)
• 色: red to dark red
• 溶解性: methanol: 10 mg/mL at 20 °C, clear, dark red
• 保管温度: 2-8°C
• SMILES記法: Cl.C[C@H](CNC(=O)CC[C@]1(C)[C@@H](CC(N)=O)[C@H]2N([Co+]O)C1=C(C)C3=NC(=CC4=NC(=C(C)C5=N[C@]2(C)[C@@](C)(CC(N)=O)[C@@H]5CCC(N)=O)[C@@](C)(CC(N)=O)[C@@H]4CCC(N)=O)C(C)(C)[C@@H]3CCC(N)=O)OP([O-])(=O)O[C@H]6[C@@H](O)[C@H](O[C@@H]6CO)n7cnc8cc(C)c(C)cc78
• InChI: 1S/C62H90N13O14P.ClH.Co.H2O/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;;;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);1H;;1H2/q;;+3;/p-3/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57+,59-,60+,61+,62+;;;/m1.../s1
• InChI Key: KEHNCSYXYMMUCO-BXSGNKEGSA-K

詳細

アプリケーション

Vitamin B12a hydrochloride has been used as an antidote for cyanide poisoning.

生物化学的／生理学的作用

Vitamin B12 (cobalamin) refers to a group of chemically-related cobalt containing molecules involved in cell processes such as DNA synthesis, fatty acid synthesis, energy production and regulation. The physiologically active forms of vitamin B12 include methylcobalamin and adenosylcobalamin, whereas hydroxocobalamin (vitamin B12a, OHCbl) and cyanocobalamin (CNCbl) are storage and delivery forms. Bacteria-derived hydroxocobalamin (OHCbl) and CNCbl are converted in humans to useful coenzyme forms to support metabolic processes such as mitochondrial methylmalonylcoenzyme A mutase conversion of methylmalonic acid (MMA) to succinate to link lipid and carbohydrate metabolism, and activation of methionine synthase, the rate limiting step in the synthesis of methionine.

その他情報

総説

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)