C2773

コレステロール 5α,6α-エポキシド

• 別名: 5α,6α-エポキシコレスタン-3β-オール
• 実験式（ヒル表記法）: C₂₇H₄₆O₂
• CAS番号: 1250-95-9
• 分子量: 402.65
• EC Number: 215-007-6
• MDL番号: MFCD00046980
• UNSPSCコード: 41141804
• PubChem Substance ID: 24892526
• NACRES: NA.77

特性

• アッセイ: ≥80%
• 品質水準: 100
• 形状: powder
• 官能基: epoxy
• 輸送温度: ambient
• 保管温度: room temp
• SMILES記法: [H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)[C@@]3(O4)[C@@H]4C2)([H])CC[C@@]5(C)[C@@]1([H])CC[C@]5([H])[C@]([H])(C)CCCC(C)C
• InChI: 1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-20-15-24-27(29-24)16-19(28)11-14-26(27,5)23(20)12-13-25(21,22)4/h17-24,28H,6-16H2,1-5H3/t18-,19+,20+,21-,22+,23+,24+,25-,26-,27+/m1/s1
• InChI Key: PRYIJAGAEJZDBO-ZEQHCUNVSA-N

詳細

アプリケーション

Cholesterol 5α, 6α-epoxide was incorporated in culture medium of human arterial endothelial cells to study oxysterol-induced toxicity.

生物化学的／生理学的作用

Cholesterol 5α, 6α-epoxide is an oxysterol, a cholesterol derivative by auto-oxidation. Oxysterols are non-genomic regulators of cholesterol homeostasis. The biological effects include protein prenylation, apoptosis, modulation of sphingolipid metabolism and platelet aggregation. Oxysterols bind to liver X receptors, modulate cholesterol efflux and decrease the uptake of cholesterol by the cells.

調製ノート

Cholesterol 5α, 6α-epoxide yields clear, colorless solution in chloroform at 50 mg/ml.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)