E2656

(−)-Epothilone B

from Sorangium cellulosum, ≥98% (HPLC)

• 別名: EPO906, EpoB, Patupilone
• 実験式（ヒル表記法）: C₂₇H₄₁NO₆S
• CAS番号: 152044-54-7
• 分子量: 507.68
• MDL番号: MFCD02101921
• UNSPSCコード: 12352200
• PubChem Substance ID: 24724475
• NACRES: NA.77

特性

• 由来生物: Sorangium cellulosum
• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: lyophilized powder
• 保管条件: desiccated; protect from light
• 色: white to off-white
• 保管温度: −20°C
• SMILES記法: [H][C@]1(C[C@]2([H])O[C@]2(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)\C(C)=C\c3csc(C)n3
• InChI: 1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15)31/h11,14-15,17,20-22,24,29,31H,8-10,12-13H2,1-7H3/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1
• InChI Key: QXRSDHAAWVKZLJ-PVYNADRNSA-N

詳細

詳細

Epothilones has antimitotic properties. It prevents microtubule depolymerization and competitively blocks paclitaxel binding to microtubules. Epothilone B is used to treat metastatic breast cancer (MBC).

生物化学的／生理学的作用

(-)-Epothilone B is a microtubule (MT) stabilizing drug and natural macrolide antitumor from myxobacteria Sorangium cellulosum. EpoB has similar biological properties to EpoA. However, EpoB is 10-fold more potent than EpoA against P-glycoprotein-expressing multidrug resistant (MDR) cells (IC₅₀ = 2 nM for MDR CCRF-CEM/VBL₁₀₀ cells). (-)-Epothilone B is similar to paclitaxel in binding displacement, and a substitution for paclitaxel in dependent cell growth. EpoB causes cell cycle arrest (IC₅₀ = 3.5 nM).

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable