F100

Fluspirilene

• 別名: R 6218
• 実験式（ヒル表記法）: C₂₉H₃₁F₂N₃O
• CAS番号: 1841-19-6
• 分子量: 475.57
• EC Number: 217-418-6
• MDL番号: MFCD00055137
• UNSPSCコード: 12352200
• PubChem Substance ID: 24277915
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• フォーム: solid
• 色: white
• 溶解性: DMSO: ≥20 mg/mL; H₂O: insoluble; ethanol: soluble
• オーガナイザー: Johnson & Johnson
• 保管温度: room temp
• SMILES記法: Fc1ccc(cc1)C(CCCN2CCC3(CC2)N(CNC3=O)c4ccccc4)c5ccc(F)cc5
• InChI: 1S/C29H31F2N3O/c30-24-12-8-22(9-13-24)27(23-10-14-25(31)15-11-23)7-4-18-33-19-16-29(17-20-33)28(35)32-21-34(29)26-5-2-1-3-6-26/h1-3,5-6,8-15,27H,4,7,16-21H2,(H,32,35)
• InChI Key: QOYHHIBFXOOADH-UHFFFAOYSA-N
• 遺伝子情報: human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816)

詳細

アプリケーション

Fluspirilene has been used as a neuroleptic drug to study its effects on human ether-a-go-go related gene (HERG).

Fluspirilene has been used to study its cytotoxicity effect on malignant glioma.

生物化学的／生理学的作用

Fluspirilene has a potential to inhibit the activity of cyclin-dependent kinase 2 (CDK2). It is an effective anti-cancer agent used for treating human hepatocellular carcinoma.

Fluspirilene is a dopamine receptor antagonist. It also acts as a calcium channel blocker. Fluspirilene is an antipsychotic agent and exhibits neuoleptic properties. It exhibits therapeutic effects against glioblastoma and Schizophrenia.

特徴および利点

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)