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由来生物
human
品質水準
リコンビナント
expressed in CHO cells
アッセイ
>97% (visualized with silver stain, SDS-PAGE)
形状
lyophilized powder
分子量
dimer 13 kDa (based on N-terminal sequencing, starting at the first histidine of the 6X histidine tag)
テクニック
cell culture | mammalian: suitable
不純物
endotoxin, tested
UniProtアクセッション番号
保管温度
−20°C
遺伝子情報
human ... GDF15(9518)
詳細
Growth-differentiation factor-15 (GDF-15) is a stress-responsive member of the transforming growth factor-β cytokine superfamily. It is also known as PTGF-Growth-differentiation factor-15 (GDF-15) and is a stress-responsive member of the transforming growth factor-β cytokine superfamily.2 It is also known as PTGF-β, TGF-PL or MIC-1β, TGF-PL or MIC-1.
アプリケーション
Growth-differentiation factor-15 (GDF-15) has been associated in the regulation of cell survival, proliferation, and differentiation and also in the protection from ischemia/reperfusion injury. Inflammatory and apoptotic pathways are regulated in injured tissues by GDFs during disease processes.
生物化学的／生理学的作用
Although it has been classified as a divergent member of the transforming growth factor-β superfamily, GDF-15 shares structural characteristics with this superfamily. It has been identified as a biomarker for human prostate cancer. Additionally, increased GDF-15 expression has been observed in breast, pancreas and colorectal cancers. Functions of this cytokine include inhibition of TNF-α production, initiation of cartilage formation, and promotion of neuronal survival.
It has been discussed to serve as a secreted biomarker for activation of the p53 pathway in human cancer.
It has been discussed to serve as a secreted biomarker for activation of the p53 pathway in human cancer.
物理的形状
凍結乾燥品(0.2 μmフィルターで濾過滅菌済みの30% アセトニトリル、0.1% トリフルオロ酢酸溶液から調製。GDF-15 1μgにつき50 μgのウシ血清アルブミンを含有)。
アナリシスノート
還元条件下のSDS-PAGEで、GDF-15組み換え体の各モノマ-は約14 kDaのタンパク質として泳動します。
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
G3046-BULK:
G3046-25UG-PW:
G3046-25UG:4548173301532
G3046-VAR:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Renal failure and the histopathological features of myeloma kidney reversed by intensive chemotherapy and peritoneal dialysis.
P E Rose et al.
British medical journal (Clinical research ed.), 294(6569), 411-412 (1987-02-14)
K P Bland et al.
Quarterly journal of experimental physiology (Cambridge, England), 74(6), 813-824 (1989-11-01)
In order to examine whether an aspiration mechanism exists in the vomeronasal organ (VNO) of the domestic ram, experiments were conducted in chloralose-anaesthetized animals using acute electromanometry and electrophysiological techniques. Stimulation of the ipsilateral cervical sympathetic nerve activated a mechanism
Jennifer Lee et al.
PloS one, 10(6), e0131506-e0131506 (2015-06-27)
Although inactivating frameshift mutations in the Transforming growth factor beta receptor type 2 (TGFBR2) gene are considered as drivers of microsatellite unstable (MSI) colorectal tumorigenesis, consequential alterations of the downstream target proteome are not resolved completely. Applying a click-it chemistry
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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