M8316

抗MRP2 ウサギ宿主抗体

affinity isolated antibody, buffered aqueous solution

• 別名: 抗ABCC2抗体, 抗cMOAT抗体, 抗cMRP抗体, 抗多剤耐性関連タンパク質2抗体
• MDL番号: MFCD01865475
• UNSPSCコード: 12352203
• NACRES: NA.41
• 結合体: unconjugated
• application: IF; WB
• クローン: polyclonal
• 化学種の反応性: rat, human
• citations: 20
• テクニック: indirect immunofluorescence: 1:100 using paraformaldehyde-fixed HepG2 cells; indirect immunofluorescence: 1:100 using rat liver frozen sections; western blot: 1:1,000 using whole extract of HepG2 human hepatoblastoma cells

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen ~190 kDa
• 化学種の反応性: rat, human
• テクニック: indirect immunofluorescence: 1:100 using paraformaldehyde-fixed HepG2 cells; indirect immunofluorescence: 1:100 using rat liver frozen sections; western blot: 1:1,000 using whole extract of HepG2 human hepatoblastoma cells
• UniProtアクセッション番号: Q92887
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... ABCC2(1244) ; rat ... Abcc2(25303)

詳細

詳細

Multidrug Resistance-associated Protein 2 (MRP2), also called as canalicular Multispecific Organic Anion Transporter (cMOAT), is a member of the CFTR/MRP (ABCC) subfamily of the large ATP-Binding Cassette (ABC) transporter family of transmembrane proteins. MRP2 is normally expressed in the liver, gallbladder, kidney proximal tubules, placenta, duodenum and small intestine. Localization pattern appears to vary in different species. MRP2 is predominantly localized to the apical membrane of polarized cells.

Multidrug resistance associated protein 2 (MRP2) is expressed in endothelial cells of the blood-brain barrier, various carcinoma cell lines and tumors. The gene encoding MRP2 is localized on human chromosome 10q24 and consists of 32 exons.

特異性

約175 kDaのバンドなど、未成熟の非グリコシル化型に相当する低分子量のバンドが多くの抽出サンプルで検出される場合があります。

免疫原

ヒトMRP2のアミノ酸1528-1545に相当する合成C末端ペプチドのKLH結合体。

アプリケーション

Anti-MRP2 antibody produced in rabbit has been used in:

• immunoblotting
• western blotting
• immunofluorescence

生物化学的／生理学的作用

Multidrug Resistance-associated Protein 2 (MRP2) transports endogenous and exogenous anionic conjugates from hepatocytes to the bile. Thus, it contributes to bile flow and plays a role in detoxification and defense against oxidative stress. Patients with the rare autosomal recessive Dubin-Johnson Syndrome develop a mild liver disease caused by MRP2 deficiency. Up regulation of MRP2 expression may be found in hepatocellular carcinomas.

Multidrug resistance associated protein 2 (MRP2) is a transporter which is involved in the efflux of various xenobiotic compounds like doxorubicin and methotrexate.

物理的形状

0.01M PBS溶液 (pH 7.4, 1%BSA, 15mMアジ化ナトリウム含有)。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable