O3764

Oxcarbazepine

≥98% (HPLC), solid

• 別名: 10,11-Dihydro-10-oxo-5h-dibenz[b,f]azepine-5-carboxamide, Oxacarbazepine
• 実験式（ヒル表記法）: C₁₅H₁₂N₂O₂
• CAS番号: 28721-07-5
• 分子量: 252.27
• EC Number: 249-188-8
• MDL番号: MFCD00865307
• UNSPSCコード: 12352200
• PubChem Substance ID: 24724563
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: solid
• 色: white
• 溶解性: DMSO: ~9 mg/mL
• オーガナイザー: Novartis
• SMILES記法: O=C1CC2=C(C=CC=C2)N(C(N)=O)C3=CC=CC=C31
• InChI: 1S/C15H12N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8H,9H2,(H2,16,19)
• InChI Key: CTRLABGOLIVAIY-UHFFFAOYSA-N
• 遺伝子情報: human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335) ; rat ... Scnn1g(24768)

詳細

詳細

Oxcarbazepine (OXC) is the keto-analog of carbamazepine. Unlike carbamazepine, oxcarbazepine has no side effects. It is an antiepileptic drug, with an antineuralgic property. It has a pharmacokinetic advantage over carbamazepine. It is prescribed for neuropathic pain and serves as an effective pain reliever in trigeminal neuralgia. The catabolism of OXC to its monohydroxy derivative has significant pharmacologic property. It modulates potassium channels and voltage-dependent sodium channels. OXC modulates V2 receptor-G protein complex in collecting tubules and is used for treating diabetes insipidus.

アプリケーション

Oxcarbazepine has been used in reversed-phase high-performance liquid chromatography of human epileptic brain endothelial cells.

生物化学的／生理学的作用

Anticonvulsant, antineuralgic. Inhibits veratrine-induced transmitter release.

特徴および利点

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302
• 注意書き: P264 - P270 - P301 + P312 - P501
• 危険有害性の分類: Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)