P0106

ペフロキサシン メシル酸塩 二水和物

• 別名: 3-キノリンカルボン酸, 1-エチル-6-フルオロ-1,4-ジヒドロ-7-(4-メチル-1-ピペラジニル)-4-オキソ-, モノメタンスルホン酸, 二水和物, ペフロキサシウム メタンスルホナート二水和物, ペフロキサシンモノメタンスルホン酸二水和物
• 化学式: C₁₇H₂₀FN₃O₃ • CH₄O₃S • 2H₂O
• CAS番号: 149676-40-4
• 分子量: 465.49
• EC Number: 274-613-9
• MDL番号: MFCD01685696
• UNSPSCコード: 51102829
• PubChem Substance ID: 329820015
• NACRES: NA.76

特性

• 形状: powder
• 品質水準: 100
• 溶解性: H₂O: 50 mg/mL
• 抗生物質活性スペクトル: Gram-negative bacteria; Gram-positive bacteria
• 作用機序: DNA synthesis | interferes; enzyme | inhibits
• 保管温度: 2-8°C
• SMILES記法: O.O.CS(O)(=O)=O.CCN1C=C(C(O)=O)C(=O)c2cc(F)c(cc12)N3CCN(C)CC3
• InChI: 1S/C17H20FN3O3.CH4O3S.2H2O/c1-3-20-10-12(17(23)24)16(22)11-8-13(18)15(9-14(11)20)21-6-4-19(2)5-7-21;1-5(2,3)4;;/h8-10H,3-7H2,1-2H3,(H,23,24);1H3,(H,2,3,4);2*1H2
• InChI Key: LEULAXMUNMRLPW-UHFFFAOYSA-N

詳細

詳細

Chemical structure: fluoroquinolone

アプリケーション

Pefloxacin is a synthetic broad-spectrum fluoroquinolone antibiotic that is effective against most gram-negative and gram-positive bacteria. It is used to treat gonococcal urethritis and for gram-negative-bacterial infections in the gastrointestinal system and the genitourinary tract. Pefloxacin mesylate dihydrate has been used to induce achilles tendon toxicity in rodents. It′s cytotoxicity and uptake have been studied in primary cultures of rat hepatocytes.

生物化学的／生理学的作用

Pefloxacin inhibits the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase is thought to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV is thought to be the primary target in gram-positive organisms. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited . Pefloxacin is an analog of norfloxacin.

その他情報

Keep container tightly closed in a dry and well-ventilated place.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H319
• 注意書き: P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves