P5057

パロモマイシン 硫酸塩

powder, suitable for cell culture, BioReagent

• 実験式（ヒル表記法）: C₂₃H₄₅N₅O₁₄ · xH₂SO₄
• CAS番号: 1263-89-4
• 分子量: 615.63 (free base basis)
• Beilstein: 5715182
• UNSPSCコード: 12352207
• PubChem Substance ID: 24898585
• NACRES: NA.76

特性

• 製品名: パロモマイシン 硫酸塩, powder, BioReagent, suitable for cell culture, potency: ≥675 μg per mg
• 製品種目: BioReagent
• 品質水準: 200
• フォーム: powder
• 有効性: ≥675 μg per mg
• テクニック: cell culture | mammalian: suitable
• 抗生物質活性スペクトル: Gram-negative bacteria; Gram-positive bacteria
• 作用機序: protein synthesis | interferes
• SMILES記法: O[C@H]1[C@H](O)[C@@H](CO)O[C@H](O[C@@]2([H])[C@H](O[C@@]3([H])[C@H](O)[C@H](O[C@]4([H])[C@H](N)[C@@H](O)[C@H](O)[C@H](CN)O4)[C@@H](CO)O3)[C@@H](O)[C@H](N)C[C@@H]2N)[C@@H]1N.C
• InChI: 1S/C23H45N5O14.CH4/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;/h5-23,29-36H,1-4,24-28H2;1H4/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1
• InChI Key: OYJABWUHUYVDMJ-UDXJMMFXSA-N

詳細

詳細

Chemical structure: aminoglycoside

Paromomycin or aminosidine, an aminoglycoside belongs to the class of aminoglycosides. This nonabsorbable antibiotic is found at high level in the lumen of the colon.

アプリケーション

• Paromomycin sulfate salt has been used as a:
• reference compound in antileishmanial activity
• RNA-binding ligand and interacts with aptamer. This interaction prevents the binding (and cutting) of dicer to RNA duplex.

Recommended for use in cell culture applications at 100mg/L.

Paromomycin sulfate salt has been used as a positive control to compare the purine analog antiviral 2′,3′-dideoxyinosine (ddI).

生物化学的／生理学的作用

パロモマイシンは、16SリボソームRNAに結合することで、タンパク質合成の開始段階及び伸長段階を阻害します。 パロモマイシンはA部位に結合し、これにより産生されるポリペプチド鎖に欠陥が生じ、細胞死に至ります。

抗菌スペクトル:グラム陰性菌、グラム陽性菌、原生生物の一部、および限定的な駆虫性作用。
作用機序:タンパク質合成の開始と伸長を阻害します。

Paromomycin possesses antileishmanial and antibacterial activities. It is used to cure visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL). This aminocyclitol glycoside is active against gram-negative and gram-positive bacteria. It is also active against E. histolytica, D. fragilis and several cestodes, like Taenia saginata, Taenia solium etc.

その他情報

1g,5g

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable