P8386

フェニルブタゾン

• 別名: 4-ブチル-1,2-ジフェニル-3,5-ピラゾリジンジオン
• 実験式（ヒル表記法）: C₁₉H₂₀N₂O₂
• CAS番号: 50-33-9
• 分子量: 308.37
• EC Number: 200-029-0
• MDL番号: MFCD00005500
• UNSPSCコード: 12352200
• PubChem Substance ID: 24277729
• NACRES: NA.77

特性

• 由来生物: synthetic (organic)
• 品質水準: 200
• アッセイ: ≥98% (HPLC)
• 形状: powder
• mp: 106-108 °C (lit.)
• 溶解性: ethanol: 50 mg/mL, clear, colorless to light yellow
• SMILES記法: CCCCC1C(=O)N(N(C1=O)c2ccccc2)c3ccccc3
• InChI: 1S/C19H20N2O2/c1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)16-12-8-5-9-13-16/h4-13,17H,2-3,14H2,1H3
• InChI Key: VYMDGNCVAMGZFE-UHFFFAOYSA-N
• 遺伝子情報: human ... CYP2C9(1559) , PTGIS(5740) , PTGS1(5742) , PTGS2(5743)

詳細

アプリケーション

Phenylbutazone has been used:

• as a hepatotoxin in transgenic zebrafish line (LiPan) hepatotoxin assay
• as a standard in high-performance liquid chromatography-ultraviolet (HPLC-UV) method
• as an anti-inflammatory compound in hen′s egg chorioallantoic membrane test (HET-CAM assay)

生物化学的／生理学的作用

Phenylbutazone is a hepatotoxin and binds to plasma proteins. It is used to treat inflammation in horse. Phenylbutazone has potential to treat ankylosing spondylitis. It has therapeutic potential to treat myotonic dystrophy type 1 (DM1) by inducing muscle blind-like protein 1 (MBNL1) expression. It also favors the expression of muscle chloride channel in skeletal muscles.

基質

非ステロイド性抗炎症薬です。シクロオキシゲナ-ゼインヒビタ-であり、シクロオキシゲナ-ゼによる過酸化の基質でもあります。

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H301,H312 + H332,H315,H319,H335
• 注意書き: P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Faceshields, Gloves