S5013

サルブタモール ヘミ硫酸塩

≥98%

• 別名: α-([t-ブチルアミノ]メチル)-4-ヒドロキシ-m-キシレン-α,α′-ジオール, アルブテロール
• 化学式: C₁₃H₂₁NO₃ · 1/2H₂SO₄
• CAS番号: 51022-70-9
• 分子量: 288.35
• EC Number: 256-916-8
• MDL番号: MFCD00055200
• UNSPSCコード: 12352200
• PubChem Substance ID: 24277746
• NACRES: NA.77

特性

• 品質水準: 200
• アッセイ: ≥98%
• 溶解性: 1 M NaOH: 50 mg/ml, clear to slightly hazy, yellow-green
• オーガナイザー: GlaxoSmithKline
• SMILES記法: OS(O)(=O)=O.CC(C)(C)NCC(O)c1ccc(O)c(CO)c1.CC(C)(C)NCC(O)c2ccc(O)c(CO)c2
• InChI: 1S/2C13H21NO3.H2O4S/c2*1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15;1-5(2,3)4/h2*4-6,12,14-17H,7-8H2,1-3H3;(H2,1,2,3,4)
• InChI Key: BNPSSFBOAGDEEL-UHFFFAOYSA-N
• 遺伝子情報: human ... ADRB2(154)

詳細

アプリケーション

Salbutamol hemisulfate salt has been used as reference standards of drugs for the validation of β-agonist residue.

Salbutamol hemisulfate salt was used as standard in analysis of fortified meat for LABA content using ELISA kits.³ It was used to study the response of prostaglandin 2α to various β-adrenergic agonists in cultured bovine endometrial cells.⁴

生物化学的／生理学的作用

Salbutamol is a β2 adrenoceptor agonist with short acting bronchodilation and anti-inflammatory effects. It relaxes the airway smooth muscles and inhibits bronchoconstriction induced by adenosine-5′ -monophosphate (AMP). Salbutamol is particularly effective in treatment of asthma as it provides immediate relief. Salbutamol is one of the most popular short-acting BA (SABA). It is useful in treating the symptoms of EIB (exercise induced bronchospasm).

Salbutamol is a β2 adrenoceptor agonist with short acting bronchodilation and anti-inflammatory effects. It relaxes the airway smooth muscles and inhibits bronchoconstriction induced by adenosine-5′ -monophosphate (AMP).¹ Salbutamol is particularly effective in treatment of asthma as it provides immediate relief.²

β2-Adrenergic receptor agonist.

特徴および利点

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• ピクトグラム: GHS08,GHS07
• シグナルワード: Warning
• 危険有害性情報: H317,H351,H361fd
• 注意書き: P202 - P261 - P272 - P280 - P302 + P352 - P308 + P313
• 危険有害性の分類: Carc. 2 - Repr. 2 - Skin Sens. 1
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)