S7389

SB-269970 塩酸塩

powder, ≥98% (HPLC)

• 別名: (R)-3-[2-[2-(4-メチルピペリジン-1-イル)エチル]ピロリジン-1-スルホニル]フェノール 塩酸塩, SB 269970A
• 実験式（ヒル表記法）: C₁₈H₂₈N₂O₃S · HCl
• CAS番号: 261901-57-9
• 分子量: 388.95
• MDL番号: MFCD03788020
• UNSPSCコード: 12352200
• PubChem Substance ID: 24278708
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 光学活性: [α]/D 75 to 90°, c = 1.0 in DMSO
• 保管条件: desiccated
• 溶解性: H₂O: 10 mg/mL, clear (warmed to 60 °C)
• 保管温度: 2-8°C
• SMILES記法: Cl.CC1CCN(CC1)CC[C@H]2CCCN2S(=O)(=O)c3cccc(O)c3
• InChI: 1S/C18H28N2O3S.ClH/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18;/h2,5-6,14-16,21H,3-4,7-13H2,1H3;1H/t16-;/m1./s1
• InChI Key: XQCJOYZLWFNDIO-PKLMIRHRSA-N
• 遺伝子情報: human ... HTR7(3363)

詳細

アプリケーション

SB-269970 hydrochloride has been used to study the effect of different endotype combination on the activity of the 5-hydroxytryptamine receptor of tall fescue alkaloids. It has also been used to inhibit dopamine receptor signaling, in order to study its role in early hemocyte activation.

SB-269970 was used to study the role of 5-HT₇ receptors in serotonin-induced hypothermia in rodents.⁶

生物化学的／生理学的作用

SB-269970 is an anti-psychotic agent that shows high affinity for 5-HT₇ receptors. It may be effective in treating cognitive disabilities and schizophrenia-like deficits.⁴ SB-269970 desensitizes and decreases the excitatory effects of 5-HT₇ receptors in rat hippocampus.⁵

5-HT₇ セロトニンレセプタ-の選択的アンタゴニスト。

法的情報

GlaxoSmithKline Pharmaceuticalsの許諾を得て販売を行っています。

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)